Abstract
OBJECTIVE: The aim of this study was to compare the neonatal nucleated red blood cell counts
in preterm infants in the presence and absence of clinical and histologic chorioamnionitis
while controlling for gestational age and birth weight percentile. STUDY DESIGN: Nucleated red blood cell counts were obtained from preterm infants delivered after
preterm labor or preterm premature rupture of membranes. Patients were divided on
the basis of clinical and histologic chorioamnionitis. Nucleated red blood cell counts
between groups were compared, and regression analysis controlling for gestational
age and birth weight percentile was performed. RESULTS: Of 359 patients, both measures of infection status were significantly associated
with increased nucleated red blood cell counts. In the regression analysis histologic
chorioamnionitis retained significance, whereas clinical chorioamnionitis did not.
CONCLUSIONS: Histologic chorioamnionitis produces an erythropoietic response in the fetus. Whether
fetal erythropoiesis is a direct response to mediators of inflammation or whether
it is the result of a rise in erythropoietin is unknown.(Am J Obstet Gynecol 1997;177:27-30.)
Keywords
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References
- Nucleated red blood cells: a marker for fetal asphyxia.Am J Obstet Gynecol. 1994; 170 ([abstract]): 286
- Nucleated red blood cell counts in small for gestational age infants with very low birthweight.Arch Pediatr Adolesc Med. 1989; 143: 164-169
- Prenatal asphyxia, hyperlactiaemia, hypoglycemia and erythroblastosis in growth retarded fetuses.BMJ. 1987; 294: 1051-1053
- Nucleated erythrocytes in healthy infants and in infants of diabetic mothers.J Pediatr. 1989; 116: 129-131
- Limited role of fetal blood sampling in prediction of outcome in intrauterine growth retardation.Lancet. 1990; 336: 768-772
- Umbilical venous erythropoietin and umbilical arterial pH in relation to morphologic placental abnormalities.Obstet Gynecol. 1994; 84: 81-87
- Amniotic fluid erythropoietin correlates with umbilical plasma erythropoietin in normal and abnormal pregnancy.Obstet Gynecol. 1987; 69: 710-716
- Changes in serum immunoreactive erythropoietin during the menstrual cycle and normal pregnancy.Br J Obstet Gynaecol. 1983; 90: 304-311
- Erythropoietin and cord blood haemoglobin in the regulation of human fetal erythropoiesis.Br J Obstet Gynaecol. 1983; 90: 795-800
- Cord blood erythropoietin, pH, PaO2 and hematocrit following caesarean section and before labour.Biol Neonate. 1993; 63: 147-152
- Lack of maternal to fetal transfer of 125I-labelled erythropoietin in sheep.J Dev Physiol. 1991; 15: 139-143
- Cord blood erythropoietin in relation to different markers of fetal hypoxia.Obstet Gynecol. 1993; 81: 575-580
- The effects of erythropoietin on haem synthesis in mouse yolk sac and cultured fetal cells.J Embryol Exp Morphol. 1966; 15: 245-260
- Cord plasma vasopressin, erythropoietin, and hypoxanthine as indices of asphyxia at birth.Pediatr Res. 1988; 24: 490-494
- Serum immunoreactive erythropoietin of children in health and disease.Eur J Pediatr. 1990; 149: 459-464
- Immunoreactive erythropoietin concentrations in fetal and neonatal rats and the effects of hypoxia.Blood. 1986; 68: 892-899
- Temporal response of immunoreactive erythropoietin to acute hypoxemia in fetal sheep.Pediatr Res. 1986; 20: 15-19
- In premature rupture of membranes and preterm labor neonatal nucleated erythrocyte number (nRBCs) is related to histologic acute inflammation and not to placental markers of hypoxia.Am J Obstet Gynecol. 1996; 174 ([abstract]): 318
- Clinical assessment of the newborn infant.J Pediatr. 1970; 77: 1
- A standard of fetal growth for the United States of America.Am J Obstet Gynecol. 1976; 126: 555-564
- Applied linear statistical models.3rd ed. Irwin, Boston1990
- Differential effects of the hematopoietic inhibitors MIP-1alpha, TGF-beta, and TNF-alpha on cytokine-induced proliferation of subpopulations of CD34+ cells purified from cord blood and fetal liver.Exp Hematol. 1995; 23: 422-427
- Clinical implications of positive and negative hematopoietic stem cell regulators.Blood. 1991; 78: 1-19
Article Info
Publication History
Accepted:
March 11,
1997
Received in revised form:
November 20,
1996
Received:
July 10,
1996
Footnotes
☆From the Departments of Obstetrics and Gynecology and Health Quantitative Sciences, New York Medical College.
☆☆Reprint requests: Enid Leikin, MD, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Westchester County Medical Center/New York College of Medicine, Valhalla, NY 10595.
★6/1/81763
Identification
Copyright
© 1997 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
