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Parathyroid hormone–related protein levels in maternal and cord blood

      Abstract

      Objective: Our purpose was to determine the plasma levels of parathyroid hormone–related protein in normal pregnant women in each trimester, at 1 month post partum in women using different feeding methods, and in umbilical venous blood. Study design: We studied 40 healthy nonpregnant women, 90 healthy pregnant women (30 in the each trimester), and 140 postpartum women (breast-feeding 74, mixed feeding 33, bottle feeding 33). We also measured the parathyroid hormone–related protein level in umbilical venous blood in 24 women. Results: The means and SDs of the plasma parathyroid hormone–related protein level were 1.04 ± 0.11 pmol/L (0.81 to 1.26 pmol/L) in nonpregnant women, 1.06 ± 0.19 pmol/L (0.69 to 1.48 pmol/L) in pregnant women in the first trimester, 1.10 ± 0.19 pmol/L (0.80 to 1.50 pmol/L) in pregnant women in the second trimester, and 1.17 ± 0.16 pmol/L (0.86 to 1.57 pmol/L) in pregnant women in the third trimester. At postpartum month 1 the plasma level of parathyroid hormone–related protein was 1.25 ± 0.23 pmol/L (0.83 to 2.01 pmol/L) in breast-feeding women, 1.17 ± 0.16 pmol/L (0.84 to 1.53 pmol/L) in mixed-feeding women, and 1.03 ± 0.16 pmol/L (0.74 to 1.43 pmol/L) in bottle-feeding women. The umbilical venous blood level of parathyroid hormone–related protein was 1.33 ± 0.32 pmol/L (0.84 to 2.11 pmol/L). The mean plasma level of parathyroid hormone–related protein increased throughout pregnancy and was significantly high in the third trimester and closely associated with the degree of breast-feeding at 1 month post partum. The parathyroid hormone–related protein level in umbilical venous blood was significantly higher than those in any groups of pregnant women. CONCLUSIONS: Parathyroid hormone–related protein produced in the fetoplacental unit, the breast, or both can reach the maternal circulation.

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      References

        • Suva LJ
        • Winslow GA
        • Wettenhall REH
        • Hammonds RG
        • Moseley JM
        • Diefenbach-Jagger H
        • et al.
        A parathyroid hormone–related protein implicated in malignant hypercalcemia: cloning and expression.
        Science. 1987; 237: 893-896
        • Broadus AE
        • Mangin M
        • Ikeda K
        • Insogna KL
        • Weir EC
        • Burtis WJ
        • et al.
        Humoral hypercalcemia of cancer: identification of a novel parathyroid hormone–like peptide.
        N Engl J Med. 1988; 319: 556-563
        • Budayr AA
        • Halloran BP
        • King JC
        • Diep D
        • Nissenson RA
        • Strewlet GJ
        High levels of a parathyroid hormone–like protein in milk.
        Proc Natl Acad Sci U S A. 1989; 86: 7183-7185
        • Law FMK
        • Moate PJ
        • Leaver DD
        • Diefenbach-Jagger H
        • Grill V
        • Ho PW
        • et al.
        Parathyroid hormone–related protein in milk and its correlation with bovine milk calcium.
        J Endocrinol. 1991; 128: 21-26
        • Barlet JP
        • Champredon C
        • Coxam V
        • Davicco MJ
        • Tressol JC
        Parathyroid hormone–related peptide might stimulate calcium secretion into the milk of goats.
        J Endocrinol. 1992; 132: 353-359
        • Care AD
        • Caple IW
        • Abbas SK
        • Pickard DW.
        The effect of fetal thyroparathyroidectomy on the transport of calcium across the ovine placenta to the fetus.
        Placenta. 1986; 7: 417-424
        • Rodda CP
        • Kubota M
        • Heath JA
        • Ebeling PR
        • Moseley JM
        • Care AD
        • et al.
        Evidence for a novel parathyroid hormone–related protein in fetal lamb parathyroid glands and sheep placenta: comparisons with a similar protein implicated in humoral hypercalcaemia of malignancy.
        J Endocrinol. 1988; 117: 261-271
        • Khosla S
        • van Heerden JA
        • Gharib H
        • Jackson IT
        • Danks J
        • Hayman JA
        • et al.
        Parathyroid hormone–related protein and hypercalcemia secondary to massive mammary hyperplasia.
        N Engl J Med. 1993; 322: 1157
        • Lepre F
        • Grill V
        • Ho PW
        • Martin TJ
        Hypercalcemia in pregnancy and lactation associated with parathyroid hormone–related protein.
        N Engl J Med. 1993; 328: 666-667
        • Caplan RH
        • Beguin EA.
        Hypercalcemia in a calcitriol treated hypoparathyroid woman during lactation.
        Obstet Gynecol. 1990; 76: 485-489
        • Cundy T
        • Haining SA
        • Guilland-Cumming DF
        • Butler J
        • Kanis JA.
        Remission of hypoparathyroidism during lactation: evidence for a physiological role for prolactin in the regulation of vitamin D metabolism.
        Clin Endocrinol. 1987; 26: 667-674
        • Ikeda K
        • Ohno H
        • Hane M
        • Yokoi H
        • Okada M
        • Honma T
        • et al.
        Development of a sensitive two-site immunoradiometric assay for parathyroid hormone–related peptide: evidence for elevated levels in plasma from patients with adult T-cell leukemia/lymphoma and B-cell lymphoma.
        J Clin Endocrinol Metab. 1994; 79: 1322-1327
        • Gallacher SJ
        • Fraser WD
        • Owens OJ
        • Dryburgh FJ
        • Loguc FC
        • Jenkins A
        • et al.
        Changes in calciotrophic hormones and biochemical markers of bone turnover in normal human pregnancy.
        Eur J Endocrinol. 1994; 131: 369-374
        • Grill V
        • Hillary J
        • Ho PMW
        • Law FMK
        • MacIsaac RJ
        • MacIsaac IA
        • et al.
        Parathyroid hormone–related protein: a possible endocrine function in lactation.
        Clin Endocrinol. 1992; 37: 405-410
        • Seki K
        • Wada S
        • Nagata N
        • Nagata I
        Parathyroid hormone–related protein during pregnancy and perinatal period.
        Gynecol Obstet Invest. 1994; 37: 83-86
        • Cross NA
        • Hillman LS
        • Allen SH
        • Krause GF
        • Vieira NE.
        Calcium homeostasis and bone metabolism during pregnancy, lactation, and postweaning: a longitudinal study.
        Am J Clin Nutr. 1995; 61: 514-523
        • Davis OK
        • Hawkins DS
        • Rubin LP
        • Posillico JT
        • Brown EM
        • Schiff I.
        Serum parathyroid hormone (PTH) in pregnant women determined by an immunoradiometric assay for intact PTH.
        J Clin Endocrinol Metab. 1988; 67: 850-852
        • Stewart AF
        • Horst R
        • Deftos LJ
        • Cadman EC
        • Lang R
        • Broadud AE.
        Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and nonhumoral groups.
        N Engl J Med. 1980; 303: 1377-1383
        • Rude RK
        • Sharp Jr, CF
        • Fredericks RS
        • Oldam SB
        • Elbaum N
        • Link J
        • et al.
        Urinary and nephrogenous adenosine 3′,5′-monophosphate in the hypercalcemia of malignancy.
        J Clin Endocrinol Metab. 1981; 52: 765-771
        • Dobnig H
        • Kainer F
        • Stepan V
        • Winter R
        • Lipp R
        • Schaffer M
        • et al.
        Elevated parathyroid hormone–related peptide levels after human gestation: relationship to change in bone and mineral metabolism.
        J Clin Endocrinol Metab. 1995; 80: 3699-3707
        • Dahlman T
        • Sjoberg HE
        • Bucht E.
        Calcium homeostasis in normal pregnancy and puerperium: a longitudinal study.
        Acta Obstet Gynecol Scand. 1994; 73: 393-398
        • Pitkin RM
        • Reynolds WA
        • Williams GA
        • Hargis GK.
        Calcium metabolism in normal pregnancy: a longitudinal study.
        Am J Obstet Gynecol. 1979; 133: 781-790
        • Thiede MA
        The mRNA encoding a parathyroid hormone–like peptide is produced in mammary tissue in response to elevations in serum prolactin.
        Mol Endocrinol. 1989; 3: 1443-1447
        • Kletzky OA
        • Rossman F
        • Bertolli SI
        • Platt LD
        • Mishell Jr., DR
        Dynamics of human chorionic gonadotropin, prolactin, and growth hormone in serum and amniotic fluid throughout normal human pregnancy.
        Am J Obstet Gynecol. 1985; 151: 878-884
        • Thiede MA
        • Rodan GA
        Expression of a calcium-mobilizing parathyroid hormone–like peptide in lactating mammary tissue.
        Science. 1988; 242: 278-280