Placental transfer of milrinone in the nonhuman primate (baboon)


      Milrinone is an inotropic agent for short-term intravenous use in the management of congestive heart failure. The purpose of this article is to question the previously reported lack of transplacental transfer of milrinone. Loading and continuous intravenous doses, considered to be therapeutic in humans, were administered to four near-term baboons. Transplacental passage was documented, with a maternal/fetal serum ratio of approximately 4:1 found during the 3 hours of infusion. (AM J OBSTET GYNECOL 1996;174:895-6.)


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to American Journal of Obstetrics & Gynecology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Colucci W
        • Wright R
        • Braunwald C.
        New positive inotropic agents in the treatment of congestive heart failure.
        N Engl J Med. 1986; 314: 349-358
        • Santos AC
        • Baumann AL
        • Wlody D
        • Pedersen H
        • Morishima HO
        • Finster M.
        The maternal and fetal effects of milrinone and dopamine in normotensive pregnant ewes.
        AM J OBSTET GYNECOL. 1992; 166: 257-262