Advertisement

Chorionic villus sampling safety Report of World Health Organization/EURO meeting in association with the Seventh International Conference on Early Prenatal Diagnosis of Genetic Diseases, Tel-Aviv, Israel, May 21, 1994

      Abstract

      Accumulated experience of 138,996 cases of chorionic villus sampling shows that chorionic villus sampling is a safe procedure with an associated fetal loss rate comparable to that of amniocentesis. The chorionic villus sampling registry shows that chorionic villus sampling is currently performed primarily between 9 and 12 weeks' gestation and carried no increased risk of limb reduction defects: the overall incidence of limb reduction defects after chorionic villus sampling is 5.2 to 5.7 per 10,000, compared with 4.8 to 5.97 per 10,000 in the general population. Analysis of the pattern distribution of limb defects after chorionic villus sampling revealed no difference from the pattern in the general population. This applies specifically to transverse limb defects. Together with the overall incidence of limb reduction defects, these data provide no evidence for any risk for congenital malformation determined by chorionic villus sampling. Because chorionic villus sampling is currently performed generally after 8 completed weeks of pregnancy, few data are available for analysis of complications related to earlier procedures. Avoiding early chorionic villus sampling also excludes sampling in cases of early fetal death, which can be diagnosed reliably by ultrasonography at 9 weeks of pregnancy. (AM J OBSTET GYNECOL 1996;174:807-11.)

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Obstetrics & Gynecology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

      1. Risk evaluation of CVS. : World Health Organization Regional Office for Europe, Copenhagen1992 (WHO/EURO document EUR/ICP/MCH 123)
        • Kuliev AM
        • Modell B
        • Jackson L
        • et al.
        Risk evaluation of CVS.
        Prenat Diagn. 1993; 13: 197-209
        • Halliday JL
        • Lumley J
        • Sheffield LJ
        • Robinson HP
        • Renou P
        • Carlin JB
        Importance of complete follow-up of spontaneous fetal loss after amniocentesis and chorion villus sampling.
        Lancet. 1992; 340: 86-90
        • Smidt-Jensen S
        • Permin M
        • Philip J
        Sampling success and risk by transabdominal chorionic villus sampling, transcervical chorionic villus sampling and amniocentesis: a randomized study.
        Ultrasound Obstet Gynecol. 1991; 1: 86-90
        • Canadian Collaborative CVS-Amniocentesis Trial Group
        Multicentre randomised clinical trial of chorionic villus sampling and amniocentesis: final report.
        Prenat Diagn. 1992; 12: 385-476
        • Palo P
        • Piiroinen O
        • Honkonen E
        • Lakkala T
        • Aula P
        Transabdominal chorionic villus sampling and amniocentesis for prenatal diagnosis: 5 years' experience at a university centre.
        Prenat Diagn. 1994; 14: 157-162
        • Nicolaides K
        • Brizot ML
        • Patel F
        • Snijders R
        Comparison of chorionic villus sampling and amniocentesis for fetal karyotyping at 10-13 weeks' gestation.
        Lancet. 1994; 344: 435-439
        • Medical Research Council Working Party on the Evaluation of Chorionic Villus Sampling
        Medical Research Council European trial of chorionic villus sampling.
        Lancet. 1991; 337: 1491-1499
        • Froster UG
        • Baird PA
        Limb reduction defects in over one million consecutive live births.
        Teratology. 1989; 39: 127-135
        • Aro T
        • Heinonen OP
        • Saxen L
        Incidence and secular trends of congenital limb defects in Finland.
        J Epidemiol. 1982; 11: 239-244
        • Kallen B
        • Rahmani TM
        • Winberg J
        Infants with congenital limb reduction registered in the Swedish register of congenital malformations.
        Teratology. 1984; 29: 73-85
        • Carsolary E
        • Manservigi D
        • Carani GP
        • Magnani C
        • Milan M
        Limb reduction defects in Emilia Romagna, Italy: epidemiological and genetic study in 173,109 consecutive births.
        J Med Genet. 1990; 27: 353-357
        • Evans JA
        • Vitez M
        • Czeizel A
        Congenital abnormalities associated with limb deficiency defects: a population study based on cases from Hungarian Congenital Malformation Registry.
        Am J Med Genet. 1994; 49: 52-66
        • Froster UG
        • Baird PA
        Upper limb deficiencies and associated malformations: a population-based study.
        Am J Med Genet. 1992; 44: 767-781
        • Froster UG
        • Baird PA
        Amniotic band sequence and limb defects.
        Am J Med Genet. 1993; 46: 497-500
        • Froster UG
        • Baird PA
        Congenital defects of the limbs in stillbirths: data from population-based study.
        Am J Med Genet. 1993; 46: 479-482
        • Stoll C
        • Alembik Y
        • Roth MP
        Risk factors in limb reduction defects.
        Paediatr Perinat Epidemiol. 1992; 6: 323-338
        • Burton BK
        • Schulz CJ
        • Burd LI
        Limb anomalies associated with chorionic villus sampling.
        Obstet Gynecol. 1992; 79: 726-730
        • Bissonette JM
        • Busch WL
        • Buckmaster JG
        • Nesslet CL
        Factors associated with limb anomalies after chorionic villus sampling.
        Prenat Diagn. 1993; 13: 1164-1165
        • Bamforth JS
        Amniotic band sequence: Streeter's hypothesis reexamined.
        Am J Med Genet. 1992; 44: 280-287
        • Mastroiacovo P
        • Botto LD
        • Cavalcanti DP
        • Lalatta F
        • Selicorni A
        • Tozzi AE
        Birth defects following chorionic villus sampling.
        Am J Med Genet. 1992; 44: 856-864
        • Firth HV
        • Boyd PA
        • Chamberlain P
        • MacKenzie IZ
        • Morris-Kay GM
        • Huson SM
        Analysis of limb reduction defects in babies exposed to chorionic villus sampling.
        Lancet. 1994; 343: 1069-1071
        • Olney R
        • Khouri MJ
        • Botto LD
        • Mastroiacovo P
        Limb defects and gestational age at chorionic villus sampling.
        Lancet. 1994; 344: 476
        • Hsieh FJ
        • Shyu MK
        • Sheu BC
        • Lin SP
        • Chen CP
        • Huang FY
        Limb defects after chorionic villus sampling.
        Obstet Gynecol. 1995; 85: 84-88
        • Czeizel A
        • Koda I
        • Lenz W
        Smoking during pregnancy and congenital limb deficiency.
        BMJ. 1994; 308: 1473-1476
        • Van Den Anker JN
        • Van Vught EE
        • Zandwijken GRG
        • Cohen-Overbeek TE
        • Lindhout D
        Severe limb abnormalities: analysis of a cluster of five cases born during a period of 45 days.
        Am J Med Genet. 1993; 45: 659-667