Abstract
OBJECTIVES: Our purpose was to determine the feasibility and optimal techniques for prenatal
paternity testing. STUDY DESIGN: Since January 1989 we have offered prenatal paternity testing by deoxyribonucleic
acid testing. We analyzed the ability to complete the testing and the time required
to complete the testing and developed polymerase chain reaction - based tests to speed
test results. RESULTS: Before April 1990 only five of nine cases could be completed. Since that time 28
consecutive cases were successfully completed before delivery. Introduction of polymerase
chain reaction - based testing has allowed us to perform testing on uncultured chorionic
villi and to derive results within 3 weeks. CONCLUSION: Analysis of uncultured chorionic villi allows prenatal paternity testing to be completed
within the first trimester of pregnancy. Prenatal paternity testing can also be performed
on cultured amniocytes and chorionic villi. (Am J Obstet Gynecol 1996;174:1849-54.)
Keywords
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References
- Blood typing in disputed paternity cases - capabilities of American laboratories.Transfusion. 1977; 17: 521-524
- A simple method for calculating the probability of excluding paternity with any number of codominant alleles.Forensic Sci Int. 1982; 19: 93-98
- Isolation and mapping of a polymorphic DNA sequence pYNH24 on chromosome 2 (D2S44).Nucleic Acids Res. 1987; 15: 10073
- Variable number tandem repeat (VNTR) in four ethnically defined human populations.Hum Genet. 1992; 90: 86-90
- Genetic analysis of the hypervariable region flanking the human insulin gene.Am J Hum Genet. 1986; 39: 291-299
- Analysis of three restriction fragment length polymorphisms in the human type II procollagen gene.Am J Hum Genet. 1985; 37: 719-732
- PCR amplification of alleles at the D1S80 locus: comparison of a Finnish and North American Caucasian population sample and forensic casework evaluation.Am J Hum Genet. 1992; 50: 816-825
- Rapid identification of VNTR alleles of human thyroid peroxidase gene by PCR: a study in a population sample from southern Italy.Genomics. 1993; 17: 796-798
- Family studies and prenatal diagnosis in severe von Willebrand disease by polymerase chain reaction amplification of a variable number tandem repeat region of the von Willebrand factor gene.Blood. 1990; 76: 555-561
- Independence tests of VNTR alleles defined as fixed bins.Am J Hum Genet. 1993; 50: 1107-1113
- DNA fingerprinting dispute laid to rest.Nature. 1994; 371: 735-736
- Population genetics and forensic efficiency data of 4 AMPFLP's.Int J Leg Med. 1992; 104: 329-333
- Allele frequency distribution of two highly polymorphic DNA sequences in three ethnic groups and its application to the determination of paternity.Am J Hum Genet. 1986; 39: 489-501
- DNA fingerprinting.Nature. 1985; 314: 67-68
Article info
Footnotes
☆From the Reproductive Genetics Institute, Department of Obstetrics and Gynecology, Illinois Masonic Medical Center.
☆☆Reprint requests: Charles M. Strom, MD, Department of Obstetrics and Gynecology, Reproductive Genetics Institute, Illinois Masonic Medical Center, 836 Wellington Ave., Chicago, IL 60657.
★0002-9378/96 $5.00 + 0 6/6/72239
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Copyright
© 1996 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
