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Soft tissue nuchal fold in the second-trimester fetus: Standards for normal measurements compared with those in Down syndrome

  • Beryl R. Benacerraf
    Correspondence
    Reprint requests: Beryl Benacerraf, M.D., Diagnostic Ultrasound Associates, 333 Longwood Ave., Boston, MA 02115.
    Affiliations
    From the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, and the Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, and Diagnostic Ultrasound Associates.
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  • Fredric D. Frigoletto Jr.
    Affiliations
    From the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, and the Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, and Diagnostic Ultrasound Associates.
    Search for articles by this author
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      There are several reports describing the sonographic sign of a thickened nuchal fold for the prenatal sonographic detection of Down syndrome in the second trimester. We prospectively obtained normative data on the nuchal folds of 303 consecutive normal fetuses undergoing genetic amniocentesis between 15 and 20 weeks' gestation. The data show that the width of the nuchal fold was consistently between 1 and 5 mm regardless of gestational age (15 to 20 weeks). (Am J Obstet Gynecol 1987;157:1146-9.)

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      References

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