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Abstract
Retrospective studies suggest that cisplatin chemotherapy regularly leads to hypomagnesemia
and occasionally hypocalcemia. The hypomagnesemia has been attributed to renal magnesium
wasting. We examined prospectively the incidence of hypomagnesemia, magnesuria, and
hypocalcemia in 17 patients receiving chemotherapy with cisplatin. Hypomagnesemia
was found in 53% to 88% of patients, depending on the definition of hypomagnesemia.
All displayed inappropriate renal excretion of magnesium. Hypocalcemia occurred in
one of the 17 prospectively studied patients (5.8%) and in three additional retrospective
patients. Hypocalcemic patients demonstrated lower serum magnesium values, higher
fractional magnesium excretion, and evidence for reduced intestinal magnesium absorption.
We conclude that hypomagnesemia, renal magnesium wasting, and hypocalcemia occur frequently
among patients receiving cisplatin. Hypocalcemia occurs in those patients who have
the severest renal magnesium wasting, the severest hypomagnesemia, and inadequate
intestinal magnesium absorption.
Keywords
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Article Info
Publication History
Accepted:
August 26,
1985
Received:
July 15,
1985
Identification
Copyright
© 1985 Mosby. Published by Elsevier Inc. All rights reserved.
