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Disclosures: The authors report no conflict of interest.
This work was supported by grants from the Regional Valencian Ministry of Education (CIPROM/2021/058 [A.P]); Spanish Ministry of Science, Innovation and Universities (FPU17/01495 [M.M.] and FPU19/0496 [N.M.]); Instituto de Salud Carlos III (ISCIII; PI21/00170 [S.H.] co-funded by European Union, CP19/00141 [S.H.], and CD20/00116 [A.B.], co-funded by European Social Fund (ESF)"Investing in your future").
Paper presentation information: This paper was partially presented as an oral at the 69th Annual Meeting of the Society for Reproductive Investigation (SRI), March 15-19, 2022, in Denver, CO, USA.
M.M.: Conceptualization, formal analysis, investigation, visualization, and writing A.B.: methodology, support, review, and editing; N.R.: support and investigation; J.M.: investigation and resources; N.P.: investigation, support, review, and editing; A.P.: conceptualization, funding acquisition, supervision, and review; S.H.: conceptualization, funding acquisition, methodology, project administration, supervision, visualization, writing, review, and editing.
Condensation: Intraovarian injection of stem cell-secreted- and platelet-enclosed growth factors restores ovarian function and improves oocyte developmental competence in a murine model of physiological ovarian aging.
AJOG at a glance:
A. Why was the study conducted? To find an alternative treatment for patients affected by age-related infertility, who have few reproductive options.
B. What are the key findings? In a murine model, the synergy of stem cell- and platelet-secreted factors improved reproductive outcomes by enhancing the quantity and quality of aged oocytes retrieved following stimulation, restoring ovarian stroma and long-lasting folliculogenesis, while decreasing oxidative damage and apoptosis.
C. What does this study add to what is already known? A single intraovarian injection, combining the paracrine properties of stem cell- and platelet- soluble factors has the potential to become an effective treatment to rescue fertility of aged patients.