Study eligibility criteria
Study appraisal and synthesis methods
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Publication stageIn Press Journal Pre-Proof
Disclosures: The authors report no conflicts of interest.
Funding: CEA is supported by a Medical Research Council New Investigator Grant (MR/T016701/1) and the NIHR Cambridge Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. The funders had no role in in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the article for publication.
The systematic review protocol was prospectively registered in PROSPERO (CRD42021276218) on 31st August 2021.
Condensation: Adverse perinatal outcomes, including stillbirth and neonatal mortality, are significantly more likely in pregnancies complicated by cardiomyopathy compared to non-cardiomyopathy or no cardiac disease.
AJOG at a glance:
A. Adverse perinatal outcomes are common in pregnancies complicated by cardiac disease. The magnitude of risk for neonates of women with cardiomyopathy compared to healthy women and women with other forms of cardiac disease has not been explored
B. Perinatal death is significantly more likely in pregnancies complicated by cardiomyopathy than pregnancies with no cardiac disease or other forms of cardiac disease. Cardiomyopathy also confers a significantly increased risk of pre-term delivery and small-for-gestational-age neonates compared with no or other forms of cardiac disease.
C. Women with cardiomyopathy be made aware of the magnitude of risk for their fetuses and neonates, and their pregnancies should be managed in multidisciplinary teams of experts, including close fetal monitoring where possible