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TRUFFLE-2 Feasibility Study Authors:
Bine Arabin, Astrid Berger, Eva Bergman, Amarnath Bhide, Caterina M. Bilardo, Andrew C. Breeze, Jana Brodszki, Pavel Calda, Elena Cesari, Irene Cetin, Jan B. Derks, Catherine Ebbing, Enrico Ferrazzi, Tiziana Frusca, Wessel Ganzevoort, Sanne J. Gordijn, Wilfried Gyselaers, Kurt Hecher, Philipp Klaritsch, Ladislav Krofta, Peter Lindgren, Silvia M. Lobmaier, Gisuseppe M. Maruotti, Federico Mecacci, Kirsti Myklestad, Rafaele. Napolitano, Federico Prefumo, Luigi Raio, Jute Richter, Ragnar K. Sande, Jim Thornton, Herbert Valensise, Gerry H. A. Visser, Ling Wee.
Conflict of interest declaration:
The authors report no conflict of interest.
CCL is supported by the UK National Institute for Health Research Biomedical Research Centre (BRC) based at Imperial College Healthcare National Health Service Trust and Imperial College.
Part of the results were presented at the online 31st World Congress on Ultrasound in Obstetrics and Gynecology, 15-17 October 2021, London, UK.
Condensation: In fetuses at risk of growth restriction, reduced growth velocity is associated with adverse perinatal outcome, irrespective of cerebral blood flow redistribution.
A. Why the study was conducted:
•To evaluate the growth velocity in fetuses at risk of growth restriction.
•To assess the association of fetal growth velocity with adverse perinatal outcome and signs of cerebral blood flow redistribution.
B. What are the key findings?
•In the last week before delivery, the fetuses with lowest growth velocity showed no growth, and in some cases negative growth.
•Fetal growth velocity <100 grams/week was associated with adverse perinatal outcome, irrespective of signs of cerebral blood flow redistribution.
C. What does this study add to what is already known?
•Fetal growth velocity is an important parameter that might identify fetuses at risk of adverse outcome irrespective of signs of cerebral blood flow redistribution, and might differentiate from constitutionally small fetuses.
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