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A genetic approach to the etiologic investigation of isolated intrauterine growth restriction

Published:August 02, 2021DOI:https://doi.org/10.1016/j.ajog.2021.07.021
      Intrauterine growth restriction (IUGR) affects 5% to 10% of pregnancies. Early diagnosis is important, because it enables the timely identification of the etiology. Clinically, the etiology may be categorized into maternal, fetal, or placental causes, however, there is considerable overlap in the pathogenesis. If adverse genetic defects can be excluded, pregnancies affected by IUGR can proceed with adequate monitoring of the fetal status to minimize risks for premature birth and intrauterine hypoxia.
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      Linked Article

      • Reply: Evidence to support offering chromosomal microarray analysis for isolated fetal growth restriction
        American Journal of Obstetrics & GynecologyVol. 225Issue 6
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          We thank Li and colleagues for their interest in our work.1 In 2020, the Society for Maternal-Fetal Medicine recommended that prenatal chromosomal microarray analysis (CMA) be offered in cases of unexplained isolated fetal growth restriction (FGR).2 This grade 1C recommendation was mainly based on 1 meta-analysis of 9 observational studies; most studies were retrospective single-center studies, including <115 fetuses. However, based on the results from our study, Li and colleagues argued that we did not have enough evidence to conclude for offering CMA in cases of isolated FGR.
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