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Reply: Regarding “Effectiveness of Chlamydia trachomatis expedited partner therapy in pregnancy”

      We appreciate the interest in our recent report on the real-world effectiveness of Chlamydia trachomatis expedited partner therapy (EPT) in pregnancy.
      • Zofkie A.C.
      • Fomina Y.Y.
      • Roberts S.W.
      • McIntire D.D.
      • Nelson D.B.
      • Adhikari E.H.
      Effectiveness of Chlamydia trachomatis expedited partner therapy in pregnancy.
      As has been well described, there are potential barriers at all levels of implementation of EPT, including concerns about partner adverse events, physician liability and malpractice, payment for medications, intimate partner violence, and the fact that most community pharmacists were unaware of EPT per a recent assessment.
      • Mmeje O.O.
      • Qin J.Z.
      • Wetmore M.K.
      • Kolenic G.E.
      • Diniz C.P.
      • Coleman J.S.
      Breakdown in the expedited partner therapy treatment cascade: from reproductive healthcare provider to the pharmacist.
      Golden et al
      • Golden M.R.
      • Whittington W.L.
      • Handsfield H.H.
      • et al.
      Effect of expedited treatment of sex partners on recurrent or persistent gonorrhea or chlamydial infection.
      also acknowledged that EPT was less effective in reducing persistent or recurrent chlamydia compared with gonorrhea in their 2005 randomized trial of men and nonpregnant women.
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      References

        • Zofkie A.C.
        • Fomina Y.Y.
        • Roberts S.W.
        • McIntire D.D.
        • Nelson D.B.
        • Adhikari E.H.
        Effectiveness of Chlamydia trachomatis expedited partner therapy in pregnancy.
        Am J Obstet Gynecol. 2021; 22 (S0002-9378(21)00468-3)
        • Mmeje O.O.
        • Qin J.Z.
        • Wetmore M.K.
        • Kolenic G.E.
        • Diniz C.P.
        • Coleman J.S.
        Breakdown in the expedited partner therapy treatment cascade: from reproductive healthcare provider to the pharmacist.
        Am J Obstet Gynecol. 2020; 223: 417.e1-417.e8
        • Golden M.R.
        • Whittington W.L.
        • Handsfield H.H.
        • et al.
        Effect of expedited treatment of sex partners on recurrent or persistent gonorrhea or chlamydial infection.
        N Engl J Med. 2005; 352: 676-685
        • Centers for Disease Control and Prevention
        Sexually transmitted disease surveillance 2019.
        (Available at:) (Accessed June 16, 2021)

      Linked Article

      • Regarding “Effectiveness of Chlamydia trachomatis expedited partner therapy in pregnancy”
        American Journal of Obstetrics & GynecologyVol. 225Issue 4
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          We read with enthusiasm the article by Zofkie et al1 in the April 2021 issue on the real-world effectiveness of an expedited partner therapy (EPT) program on reinfection among pregnant women. However, their conclusions misrepresent the study’s findings. First, the state of Texas has permitted the use of EPT since 2009, and it would be unusual if providers did not use EPT for the nearly 1000 women with Chlamydia trachomatis (CT) each year at their institution. There are many methods of partner therapy for CT, including a written prescription as EPT, which is a straightforward method that many providers use.
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