Loss of function of nitric oxide reductase associated with neisseria gonorrhoeae infection in women

      Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea, must adapt to the variable selective pressures in the anatomical sites it infects. Previous work has shown that sexual behavior—heterosexual and men-who-have-sex-with-men networks—has influenced N. gonorrhoeae population structure and that genetic variants influencing antibiotic susceptibility are adaptive for infection in particular body sites. We aimed to identify genetic variation associated with sexual behavior and site of infection.
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