The role of aspirin in prevention of preeclampsia in twin pregnancies: does the dose matter?

Published:March 12, 2020DOI:
      The use of aspirin in twin pregnancies for the prevention of preeclampsia is a controversial topic, and evidence on the required dose of aspirin is scarce. We aimed to assess the efficacy of 75 mg/day vs 150 mg/day aspirin for the prevention of preeclampsia in twin pregnancies.
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        • National Institute for Health and Care Excellence
        Hypertension in pregnancy: diagnosis and management (NICE guideline [NG133]).
        (Available at:) (Accessed Feb. 2020)
        • Rolnik D.L.
        • Wright D.
        • Poon L.C.
        • et al.
        Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia.
        N Engl J Med. 2017; 377: 613-622
        • Poon L.C.
        • Wright D.
        • Rolnik D.L.
        • et al.
        Aspirin for evidence-based preeclampsia prevention trial: effect of aspirin in prevention of preterm preeclampsia in subgroups of women according to their characteristics and medical and obstetrical history.
        Am J Obstet Gynecol. 2017; 217: 585.e581-585.e585
        • Roberge S.
        • Nicolaides K.
        • Demers S.
        • Hyett J.
        • Chaillet N.
        • Bujold E.
        The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis.
        Am J Obstet Gynecol. 2017; 216: 110-120.e116
        • Tranquilli A.L.
        • Dekker G.
        • Magee L.
        • et al.
        The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP.
        Pregnancy Hypertens. 2014; 4: 97-104