Advertisement

Polycystic ovary syndrome and lung function: a Mendelian randomization study

  • Diana A. van der Plaat
    Affiliations
    Unité Mixte de Recherche 1152, Department of Pathophysiology and Epidemiology of Respiratory Diseases, Institut National de la Santé et de la Recherche Médicale
    Unité Mixte de Recherche 1152, University Paris Diderot, Paris, France
    National Heart and Lung Institute, Imperial College London, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, United Kingdom
    Search for articles by this author
  • Cosetta Minelli
    Affiliations
    National Heart and Lung Institute, Imperial College London, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, United Kingdom
    Search for articles by this author
  • Deborah L. Jarvis
    Affiliations
    National Heart and Lung Institute, Imperial College London, Emmanuel Kaye Building, 1B Manresa Road, London SW3 6LR, United Kingdom
    Search for articles by this author
  • Judith Garcia-Aymerich
    Affiliations
    ISGlobal
    Universitat Pompeu Fabra
    Centro de Investigación Biomédica en Red Epidemiología y Salud Pública, Barcelona, Spain
    Search for articles by this author
  • Author Footnotes
    1 Contributed equally and are shared last author.
    Bénédicte Leynaert
    Footnotes
    1 Contributed equally and are shared last author.
    Affiliations
    Unité 1168, VIMA (Aging and Chronic Diseases. Epidemiological and Public Health Approaches), Institut National de la Santé et de la Recherche Médicale, Villejuif, France
    Unité Mixte de Recherche en Santé 1168, UVSQ, Université Versailles St-Quentin-en-Yvelines, St-Quentin-en-Yvelines, France
    Search for articles by this author
  • Author Footnotes
    1 Contributed equally and are shared last author.
    Francisco Gómez-Real
    Footnotes
    1 Contributed equally and are shared last author.
    Affiliations
    Department of Clinical Science, University of Bergen
    Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway
    Search for articles by this author
  • Author Footnotes
    1 Contributed equally and are shared last author.
Published:March 07, 2020DOI:https://doi.org/10.1016/j.ajog.2020.03.003
      Polycystic ovary syndrome (PCOS) is a common, but often undiagnosed, endocrine and metabolic disorder that is characterized by hyperandrogenism, polycystic ovaries, and ovulatory dysfunction.
      • Shorakae S.
      • Boyle J.
      • Teede H.
      Polycystic ovary syndrome: a common hormonal condition with major metabolic sequelae that physicians should know about.
      PCOS is associated with many health conditions, but evidence is limited regarding its effect on lung function. Oligomenorrhea, a cardinal symptom of PCOS, has been associated with low forced vital capacity (FVC), which is an important predictor of morbidity and mortality.
      • Real F.G.
      • Svanes C.
      • Omenaas E.R.
      • et al.
      Menstrual irregularity and asthma and lung function.
      Using a 2-sample Mendelian randomization (MR) approach, we estimated the causal effect of PCOS on 5 lung function outcomes, including forced expiratory volume in 1 second (FEV1), FVC, FEV1/FVC, airflow obstruction (FEV1/FVC<lower limit of normal (LLN) based on GLI-2012 [https://www.ers-education.org]), and spirometric restriction (FVC<LLN). MR studies, unlike classical observational studies, are not affected by typical confounding or reverse causation because they use single-nucleotide polymorphisms (SNPs) as proxies to derive causal estimates.
      • Davies N.M.
      • Holmes M.V.
      • Davey Smith G.
      Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic and Personal
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Obstetrics & Gynecology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Shorakae S.
        • Boyle J.
        • Teede H.
        Polycystic ovary syndrome: a common hormonal condition with major metabolic sequelae that physicians should know about.
        Intern Med J. 2014; 44: 720-726
        • Real F.G.
        • Svanes C.
        • Omenaas E.R.
        • et al.
        Menstrual irregularity and asthma and lung function.
        J Allergy Clin Immunol. 2007; 120: 557-564
        • Davies N.M.
        • Holmes M.V.
        • Davey Smith G.
        Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians.
        BMJ. 2018; 362: k601
        • Day F.
        • Karaderi T.
        • Jones M.R.
        • et al.
        Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.
        PLoS Genet. 2018; 14e1007813
        • Lawlor D.A.
        • Ebrahim S.
        • Smith G.D.
        Associations of measures of lung function with insulin resistance and type 2 diabetes: findings from the British Women’s Heart and Health Study.
        Diabetologia. 2004; 47: 195-203