- •2019-nCoV: 2019-novel coronavirus (previous name for COVID-19 and SARS-CoV-2).
- •Basic reproduction number: estimate of number of individuals who will become infected from a single person in a population in which all individuals are susceptible.
- •CDC: US Centers for Disease Control and Prevention.
- •COVID-19: coronavirus disease 2019 (previously called 2019 novel coronavirus [2019-nCoV]; illness caused by SARS-CoV-2.
- •MERS: Middle East respiratory syndrome.
- •MERS-CoV: Middle East respiratory syndrome coronavirus, virus that causes Middle East respiratory syndrome (MERS).
- •N95 respirator: respiratory protective device that removes at least 95% of very small (0.3 μm) test particles; also called N95 filtering facepiece respirator.
- •SARS: severe acute respiratory syndrome.
- •SARS-CoV: severe acute respiratory syndrome coronavirus, virus that caused severe acute respiratory syndrome (SARS).
- •SARS-CoV-2: severe acute respiratory syndrome coronavirus 2 virus (current name of the novel coronavirus, according to the International Committee on Taxonomy of Viruses), virus that causes COVID-19.
- •WHO: World Health Organization.
- World Health Organization
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SARS and its effects on pregnant women
|First patients reported||Guangdong, China, November 2002||Zarga, Jordan, April 2012, and Jeddah, Saudi Arabia, June 2012||Wuhan, China, December 2019|
|Type of coronavirus||Betacoronavirus||Betacoronavirus||Betacoronavirus|
|Host cell receptor||Angiotensin converting enzyme 2||Dipeptidyl peptidase 4||Structural analysis suggests angiotensin converting enzyme 2 receptor|
|Sequence similarity||Reference||79% to SARS-CoV, 50% to MERS-CoV|
|Animal hosts||Bats (natural reservoir), masked palm civet and raccoon dogs may be intermediate hosts||Bats (natural reservoir), dromedary camel (intermediate host)||Bats, animals sold at the seafood market in Wuhan might represent an intermediate host|
|Mean (95% CI, d)||4.6 (3.8–5.8)||5.2 (1.9–14.7)||5.2 days (95% confidence interval [CI], 4.1–7.0); 95th percentile of the distribution was 12.5 days|
|Time from illness onset until hospitalization||2–8 days||0–16 days||12.5 days (mean) (95% CI, 10.3–14.8), onset before Jan. 1|
9.1 days (mean); 95% CI, 8.6–9.7 (onset Jan. 1–11)
|Basic reproduction number (R0)|
|2–3||<1||2.2 (95% CI, 1.4–3.9)|
|Adults||93%||98%||Nearly all reported patients are adults|
|Children||5–7%||2%||Children have been infrequently reported (<1% of cases)|
|Age range, y||1–91||1–94||10–89 y|
|Average age, y||Mean, 39.9||Median, 50||59 years (median)|
|Sex ratio (M:F)||43%:57%||64.5%:35.5%||56%:44%|
|Case fatality rate overall||9.6%||35–40%||Initial estimate is 1%|
Report 4: severity of 2019-novel coronavirus (nCoV). WHO Collaborating Centre for Infectious Disease Modelling, MRC Centre for Global Infectious Disease Analysis, Imperial College London.
|Clinical manifestations||From hospitalized patients|
|Radiographic abnormalities on chest imaging||94–100%||90–100%||100%|
MERS and its effects on pregnant women
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Coronavirus disease 2019 (COVID-19)
Clinical, epidemiologic, and viral characteristics
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Implications of COVID-19 for pregnant women
Susceptibility to and severity of COVID-19 in pregnancy
Travel guidance for pregnant women
Vaccination in pregnancy
Infection control measures and diagnostic testing
|Clinical features||AND||Epidemiologic risk|
|Fever||AND||Any person, including health care workers, who has had close contact|
bwith a laboratory-confirmed COVID-19 patient within 14 days of symptom onset
Close contact is defined as follows: (1) being within ∼6 feet (2 m) of a COVID-19 case for a prolonged period of time while not wearing recommended personal protective equipment (eg, gowns, gloves, NIOSH-certified disposable N95 respirator, eye protection); close contact can occur while caring for, living with, visiting, or sharing a health care waiting area or room with a COVID-19 case; OR (2) having direct contact with infectious secretions of a COVID-19 case (eg, being coughed on) while not wearing recommended personal protective equipment.
|Fever||AND||A history of travel from Hubei Province, China, within 14 days of symptom onset|
|Fever||AND||A history of travel from mainland China within 14 days of symptom onset|
Management of COVID-19 in pregnancy
Interim infection prevention and control recommendations for patients with confirmed 2019 novel coronavirus (2019-nCoV) or patients under investigation for 2019-nCoV in healthcare settings. Centers for Disease Control and Prevention. Updated Feb. 3, 2020.
Interim guidance for implementing home care of people not requiring hospitalization for 2019 novel coronavirus (2019-nCoV). Updated Jan. 31, 2020.
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The authors report no conflict of interest.