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Appointment of Carlos Simón as Editor of Preconceptional Care and Biology for AJOG

  • Roberto Romero
    Correspondence
    Corresponding author: Roberto Romero, MD, DMedSci
    Affiliations
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health/U.S. Department of Health and Human Services, Detroit, MI
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      Dr Simón is a reproductive endocrinologist with a long career as a physician-scientist. Board certified in Obstetrics and Gynecology in Spain, he is Professor of Obstetrics and Gynecology at the University of Valencia, Spain; Senior Lecturer at the Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard University; and Adjunct Professor at the Department of Obstetrics and Gynecology at the Baylor College of Medicine.
      After receiving his MD and PhD in Genetics from the University of Valencia School of Medicine, Dr. Simón completed residency training in Obstetrics and Gynecology at the Hospital Clínico Universitario in Valencia, and postdoctoral training in Reproductive Endocrinology at the Department of Obstetrics and Gynecology, Stanford University.
      In 1994, Dr. Simón was appointed Associate Professor at the University of Valencia and, in 2007, was promoted to Professor, leading reproductive science research. From 2009 to 2011, he served as Scientific Director of the Prince Felipe Research Center, one of the top research institutions in Spain.
      Among the world's leading experts in Reproductive Biology, especially in the area of human implantation, Dr Simón's research emphasizes the dialogue between the embryo and endometrium as well as the role of endometrial stem cells in the biology of reproduction.
      • Vera-Rodriguez M.
      • Chavez S.L.
      • Rubio C.
      • Reijo Pera R.A.
      • Simón C.
      Prediction model for aneuploidy in early human embryo development revealed by single-cell analysis.
      • Simon C.
      • et al.
      Extracellular vesicles in human reproduction in health and disease.
      • Vilella F.
      • Moreno-Moya J.M.
      • Balaguer N.
      • et al.
      Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome.
      His research has led to more than 460 peer-reviewed publications, his H-index is 77, and his Google Scholar score, 103. He has edited 19 books in English, Spanish, and Portuguese, including two recent best-sellers.
      ,
      One of these books received the 2018 British Medical Association’s Medical Book Award in the Obstetrics and Gynecology category.
      His team focused on the role of the interleukin-1 system during the adhesion phase of implantation.
      • Simón C.
      • Frances A.
      • Piquette G.
      • Hendrickson M.
      • Milki A.
      • Polan M.L.
      Interleukin-1 system in the materno-trophoblast unit in human implantation: immunohistochemical evidence for autocrine/paracrine function.
      • Simón C.
      • Piquette G.N.
      • Frances A.
      • el-Danasouri I.
      • Irwin J.C.
      • Polan M.L.
      The effect of interleukin-1 beta (IL-1 beta) on the regulation of IL-1 receptor type I messenger ribonucleic acid and protein levels in cultured human endometrial stromal and glandular cells.
      • Simón C.
      • Frances A.
      • Piquette G.N.
      • et al.
      Embryonic implantation in mice is blocked by interleukin-1 receptor antagonist.
      Moreover, his work on the molecular characterization of endometrial receptivity in humans has been the subject of more than 20 publications and has led to the identification of the transcriptomic signature of human endometrial receptivity.
      • Díaz-Gimeno P.
      • Horcajadas J.A.
      • Martínez-Conejero J.A.
      • et al.
      A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature.
      ,
      • Balaguer N.
      • Moreno I.
      • Herrero M.
      • Gonzáléz-Monfort M.
      • Vilella F.
      • Simón C.
      MicroRNA-30d deficiency during preconception affects endometrial receptivity by decreasing implantation rates and impairing fetal growth.
      Clinical translation of this work yielded a patent for the creation of a customized endometrial receptivity analysis, which has been validated internationally. Furthermore, the discoveries on human endometrial receptivity were recently analyzed at the single-cell level.

      Wang W, Vilella F, Moreno I, Pan W, Simón C, Quake S. Single cell RNAseq provides a molecular and cellular cartography of changes to the human endometrium through the menstrual cycle. BioRxiv online Jun. 19, 2018; doi: https://doi.org/10.1101/350538.

      His group identified an endometrial microbiota with functional implications in early pregnancy,
      • Moreno I.
      • Codoñer F.M.
      • Vilella F.
      • et al.
      Evidence that the endometrial microbiota has an effect on implantation success or failure.
      • Moreno I.
      • Cicinelli E.
      • Garcia-Grau I.
      • et al.
      The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology.
      • Moreno I.
      • Garcia-Grau I.
      • Bau D.
      • et al.
      The first glimpse of the endometrial microbiota in early pregnancy.
      as well as a “decidual defect” in patients with severe preeclampsia, a pathology detectable at the time of delivery and persisting for years, and attributed, in part, to a deficiency in Annexin A-2.
      • Garrido-Gomez T.
      • Dominguez F.
      • Quiñonero A.
      • et al.
      Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology.
      ,
      • Garrido-Gomez T.
      • Quiñonero A.
      • Dominguez F.
      • et al.
      Preeclampsia: a defect in decidualization is associated with deficiency of Annexin A2.
      In another important paper, he reported on the differential diagnosis of leiomyomas and leiomyosarcomas using DNA and RNA sequencing.
      • Mas A.
      • Alonso R.
      • Garrido-Gómez T.
      • et al.
      The differential diagnoses of uterine leiomyomas and leiomyosarcomas using DNA and RNA sequencing.
      Dr Simón pioneered the first derivation of embryonic stem cell lines, participating in a collaborative study demonstrating the lack of genetic diversity of the most commonly used cell lines worldwide.
      • Mosher J.T.
      • Pemberton T.J.
      • Harter K.
      • et al.
      Lack of population diversity in commonly used human embryonic stem-cell lines.
      His group also confirmed the existence of and functional proof-of-concept for human endometrial stem cells.
      • Cervelló I.
      • Gil-Sanchis C.
      • Mas A.
      • et al.
      Human endometrial side population cells exhibit genotypic, phenotypic and functional features of somatic stem cells.
      • Cervelló I.
      • Mas A.
      • Gil-Sanchis C.
      • et al.
      Reconstruction of endometrium from human endometrial side population cell lines.
      • Cervelló I.
      • Gil-Sanchis C.
      • Mas A.
      • et al.
      Bone marrow-derived cells from male donors do not contribute to the endometrial side population of the recipient.
      The contributions of Dr Simón have been recognized nationally and internationally: he received the Prize Jaime I in Medical Investigation in 2011, the KY Cha Award in Stem Cell Research in 2014, the American Society for Reproductive Medicine’s Distinguished Research Award in 2016, and other awards from that Society, the Society for Reproductive Investigation (formerly the Society for Gynecologic Investigation), the Spanish Society of Obstetrics and Gynecology, and the Spanish Fertility Society.
      Throughout the years, Dr Simón’s research has been funded by 35 competitive grants from the European Commission, the National Institutes of Health, the Spanish Government, and the Valencian Government. He is also the coordinator of a multimillion-euro European Commission-funded project—the Human Uterus Cell Atlas (HUTER)—which aims to derive single-cell and spatial maps of the healthy female uterus across the lifespan.
      Dr Simón has served as Associate Editor of Human Reproduction (2001−2007) and Fertility & Sterility (2011−2016), and as Editor of Fertility & Sterility (2016−present). He also serves on the Editorial Boards of 14 scientific journals.
      We welcome Dr Simón to the AJOG obstetrical team of Editors.

      References

        • Vera-Rodriguez M.
        • Chavez S.L.
        • Rubio C.
        • Reijo Pera R.A.
        • Simón C.
        Prediction model for aneuploidy in early human embryo development revealed by single-cell analysis.
        Nat Commun. 2015; 6: 7601
        • Simon C.
        • et al.
        Extracellular vesicles in human reproduction in health and disease.
        Endocr Rev. 2018; 39: 292-332
        • Vilella F.
        • Moreno-Moya J.M.
        • Balaguer N.
        • et al.
        Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome.
        Development. 2015; 14: 3210-3221
      1. Simon C. Giudice L.C. The endometrial factor: a reproductive precision medicine approach. CRC Press, Boca Raton2017
      2. Gardner D.K. Simon C. Handbook of in vitro fertilization. 4th edition. CRC Press, Boca Raton2017
        • Simón C.
        • Frances A.
        • Piquette G.
        • Hendrickson M.
        • Milki A.
        • Polan M.L.
        Interleukin-1 system in the materno-trophoblast unit in human implantation: immunohistochemical evidence for autocrine/paracrine function.
        JCEM. 1994; 78: 847-854
        • Simón C.
        • Piquette G.N.
        • Frances A.
        • el-Danasouri I.
        • Irwin J.C.
        • Polan M.L.
        The effect of interleukin-1 beta (IL-1 beta) on the regulation of IL-1 receptor type I messenger ribonucleic acid and protein levels in cultured human endometrial stromal and glandular cells.
        JCEM. 1994; 78: 675-682
        • Simón C.
        • Frances A.
        • Piquette G.N.
        • et al.
        Embryonic implantation in mice is blocked by interleukin-1 receptor antagonist.
        Endocrinology. 1994; 134: 521-528
        • Díaz-Gimeno P.
        • Horcajadas J.A.
        • Martínez-Conejero J.A.
        • et al.
        A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature.
        Fertil Steril. 2011; 95: 50-60
        • Balaguer N.
        • Moreno I.
        • Herrero M.
        • Gonzáléz-Monfort M.
        • Vilella F.
        • Simón C.
        MicroRNA-30d deficiency during preconception affects endometrial receptivity by decreasing implantation rates and impairing fetal growth.
        Am J Obstet Gynecol. 2019; 221: 46.e1-46.e16
      3. Wang W, Vilella F, Moreno I, Pan W, Simón C, Quake S. Single cell RNAseq provides a molecular and cellular cartography of changes to the human endometrium through the menstrual cycle. BioRxiv online Jun. 19, 2018; doi: https://doi.org/10.1101/350538.

        • Moreno I.
        • Codoñer F.M.
        • Vilella F.
        • et al.
        Evidence that the endometrial microbiota has an effect on implantation success or failure.
        Am J Obstet Gynecol. 2016; 215: 684-703
        • Moreno I.
        • Cicinelli E.
        • Garcia-Grau I.
        • et al.
        The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology.
        Am J Obstet Gynecol. 2018; 218: 602
        • Moreno I.
        • Garcia-Grau I.
        • Bau D.
        • et al.
        The first glimpse of the endometrial microbiota in early pregnancy.
        Am J Obstet Gynecol. 2020; 222: 296-305
        • Garrido-Gomez T.
        • Dominguez F.
        • Quiñonero A.
        • et al.
        Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology.
        PNAS. 2017; 114: 8468-8477
        • Garrido-Gomez T.
        • Quiñonero A.
        • Dominguez F.
        • et al.
        Preeclampsia: a defect in decidualization is associated with deficiency of Annexin A2.
        Am J Obstet Gynecol. 2020; 222: 376.e1-376.e17
        • Mas A.
        • Alonso R.
        • Garrido-Gómez T.
        • et al.
        The differential diagnoses of uterine leiomyomas and leiomyosarcomas using DNA and RNA sequencing.
        Am J Obstet Gynecol. 2019; 221: 320.e1-320.e23
        • Mosher J.T.
        • Pemberton T.J.
        • Harter K.
        • et al.
        Lack of population diversity in commonly used human embryonic stem-cell lines.
        N Engl J Med. 2010; 362: 183-185
        • Cervelló I.
        • Gil-Sanchis C.
        • Mas A.
        • et al.
        Human endometrial side population cells exhibit genotypic, phenotypic and functional features of somatic stem cells.
        PLoS One. 2010; 5:e10964
        • Cervelló I.
        • Mas A.
        • Gil-Sanchis C.
        • et al.
        Reconstruction of endometrium from human endometrial side population cell lines.
        PLoS One. 2011; 6:e21221
        • Cervelló I.
        • Gil-Sanchis C.
        • Mas A.
        • et al.
        Bone marrow-derived cells from male donors do not contribute to the endometrial side population of the recipient.
        PLoS One. 2012; 7:e30260