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415: Family history of diabetes mellitus and long-term endocrine morbidity of the offspring

      Objective

      Diabetes mellitus (DM) is associated with significant maternal and perinatal morbidity, including endocrine dysfunction, cardiovascular, and renal diseases. The aim of the present study was to determine whether being born to non-diabetic mother with family history of DM increases the risk for long-term endocrine morbidity of the offspring.

      Study Design

      A population-based cohort study, comparing long-term endocrine morbidity of offspring of non-diabetic mothers with and without a family history of DM was conducted. All singleton deliveries between the years 1991-2014 in a tertiary medical center were included. Maternal DM or gestational diabetes mellitus (GDM), children with congenital malformations or chromosomal abnormalities and pregnancies without prenatal care were excluded from the study. The study groups were followed until they were 18 years of age for endocrine-related morbidity. Kaplan-Meier survival curve was used to compare cumulative incidence of long- term endocrine morbidity, and a Cox proportional hazards model was constructed to control for confounders.

      Results

      During the study period 208,728 deliveries met the inclusion criteria, of them 8.2% (n=17040) were of non- diabetic mothers with family history of DM. Offspring born to non-diabetic mothers with family history of DM had higher risk cumulative incidence of long-term endocrine morbidity as compared with those without family history of DM (Kaplan-Meier log rank test P<0.029, Figure). Using a Cox proportional hazards model, controlling for confounders such as maternal age, hypertensive disorders of pregnancy, birth-weight and caesarian delivery, being born to a non-diabetic mother with family history of DM was found to be an independent risk factor for long- term endocrine morbidity of the offspring (adjusted HR=1.24, 95% CI 1.01-1.54; P=0.043, Table).

      Conclusion

      Being born to a non-diabetic mother with a family history of DM is independently associated with higher risk for long-term endocrine morbidity of the offspring.
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