Background
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Study Design
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Article Info
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Footnotes
Supported by The Geoff and Helen Handbury Foundation , The Beischer Medical Foundation for Mothers and Babies , The Mercy Perinatal Foundation and The Kilvington Trust ; the National Health and Medical Research Foundation of Australia provided salary support to S.T. and B.W.M.; the University of Melbourne provided a CR Roper Fellowship (salary support) to N.J.H.; C.A.C. received the Discovery Academic Fellowship and the South African Medical Association PhD Bursary.
The funders had no role in the study design, the collection, analysis, and interpretation of the data, in the writing of the report, or in the decision to submit this article for publication.
This trial is registered with the Pan African Clinical Trials Registry, PACTR201 504000771349.
The authors report no conflict of interest.
Cite this article as: Cluver CA, Hannan NJ, van Papendorp E, et al. Esomeprazole to treat women with preterm preeclampsia: a randomized placebo controlled trial. Am J Obstet Gynecol 2018;219:388.e1-17.
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- ReplyAmerican Journal of Obstetrics & GynecologyVol. 220Issue 2
- Esomeprazole to treat women with preeclampsia: possible implications in the nitric oxide homeostasisAmerican Journal of Obstetrics & GynecologyVol. 220Issue 2
- PreviewWe read with interest the article by Cluver et al1 evaluating the use of proton pump inhibitor (PPI) esomeprazole to treat women with preterm preeclampsia.1 While the 40 mg of daily oral esomeprazole tested in their study did not prolong gestation in pregnancies with preterm preeclampsia or decrease circulating soluble fms-like tyrosine kinase-1 concentrations, the authors discuss that this dosage of esomeprazole may be too low to treat preterm preeclampsia and suggest that higher doses may still be effective.
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