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Human lymphocyte antigen expression in hydatidiform mole: Androgenesis following fertilization by a haploid sperm

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      Thirteen hydatidiform moles (complete moles) and lymphocytes from each parent were analyzed for human lymphocyte antigen (HLA-A and HLA-B specificities). It was demonstrated that molar tissues expressed homozygous A and B specificities which were identical to those of the father and not those of the mother. It was concluded that androgenesis was responsible for the pathogenesis of most cases of complete mole. There was homozygous expression of paternal HLA specificities which were heterozygous for A locus and/or B locus in eight of nine cases of complete mole. This suggests that these hydatidiform moles developed from an egg which was fertilized by a haploid sperm which duplicated its own chromosomes after meiosis.
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      REFERENCES

        • Vassilakos P.
        • Riotton G.
        • Kajii T.
        Hydatidiform mole: Two entities.
        Am. J. Obstet. Gynecol. 1977; 127: 167
        • Ichinoe K.
        Hydatidiform mole in the chromosomal abnormalities in gynecologic neoplasms. personal. publication, Sapporo1970: 174
        • Kajii T.
        • Ohama K.
        Androgenetic origin of hydatidiform mole.
        Nature. 1977; 268: 633
        • Wake N.
        • Takagi N.
        • Sasaki M.
        Androgenesis as a cause of hydatidiform mole.
        J. N. C. I. 1978; 60: 51
        • Jacobs P.A.
        • Hassold T.J.
        • Matsuyama A.M.
        • Newland I.M.
        Chromosome constitution of gestational trophoblastic disease.
        Lancet. 1978; 2: 49
        • Brand L.L.
        • Ray J.G.
        • Hare D.B.
        • Kayhoe D.E.
        • MacClelland J.D.
        Preliminary trials toward standardization of leukocyte typing.
        Histocompatibility Testing. Ejnar Munksgaard Foreag, Copenhagen1970: 357
        • Bonneau M.
        • Brochier J.
        • Revillard J.P.
        • Cordier G.
        • Ekladios E.
        • Dubernard J.M.
        • Traeger J.
        Immunological properties of IgG eluted from human placenta.
        Transplant. Proc. 1975; 7: 461
        • Doughty R.W.
        • Gelsthorpe K.
        Some parameters of lymphocyte antibody activity through pregnancy and further eluates of placenta material.
        Tissue Antigens. 1976; 8: 43
        • Goodfellow P.N.
        • Barnstable C.J.
        • Bodmer W.F.
        • Snary D.
        • Crumpton M.J.
        Expression of HLA system antigens on placenta.
        Transplantation. 1976; 22: 595
        • Loke J.K.
        • Joysey V.C.
        • Borland R.
        HLA antigens on human trophoblastic cells.
        Nature. 1971; 232: 503
        • Faulk W.P.
        • Temple A.
        Distribution of β2-microglobulin and HLA in chorionic villi of human placenta.
        Nature. 1976; 262: 799
        • Lawler S.D.
        • Klouda P.T.
        • Bagshawe K.D.
        Immunogenicity of molar pregnancies in the HLA system.
        Am. J. Obstet Gynecol. 1974; 120: 857
        • Yamashita K.
        • Shiina Y.
        • Domon H.
        • Matsuda S.
        • Kuroda M.
        • Yakura H.
        Leukocytotoxic antibodies in the patients with trophoblastic tumor.
        J. Jap. Sci. Obstet. Gynecol. 1975; 27: 1333
        • Linder D.
        • Pow J.
        Further evidence for post-meiotic origin of teratomas in the human female.
        Ann. Hum. Genet. 1970; 34: 21
        • Linder D.
        • McCaw B.K.
        • Hecht F.
        Parthenotic origin of benign ovarian teratomas.
        N. Engl. J. Med. 1975; 292: 63
        • Francke U.
        • Pellegrino M.
        Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6.
        Proc. Natl. Acad. Sci. U. S. A. 1977; 74: 1147
        • Tsuji Y.
        • Matusda S.
        • Hirai T.
        • Fujiwara H.
        • Hamada T.
        Selective expression of paternal HLA on the surface of hydatidiform mole cells.
        Gan. 1978; 69: 849