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Prostaglandins in the pathogenesis of the generalized Shwartzman reaction

  • Author Footnotes
    * “Chercheur Boursier” of the “Conseil de la Recherche en Santé du Québec.”
    Jean-Gilles Latour
    Correspondence
    Institut de Cardiologie de Montréal, Laboratory of Experimental Pathology, 5000 East, Belanger St., Montreal, Quebec, Canada HIT 1C8
    Footnotes
    * “Chercheur Boursier” of the “Conseil de la Recherche en Santé du Québec.”
    Affiliations
    From the Laboratory of Experimental Pathology, Institut de Cardiologie de Montréal, and Department of Pathology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
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  • Author Footnotes
    ** Fellow of the Canadian Heart Foundation.
    Claudette Leger-Gauthier
    Footnotes
    ** Fellow of the Canadian Heart Foundation.
    Affiliations
    From the Laboratory of Experimental Pathology, Institut de Cardiologie de Montréal, and Department of Pathology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
    Search for articles by this author
  • Author Footnotes
    * “Chercheur Boursier” of the “Conseil de la Recherche en Santé du Québec.”
    ** Fellow of the Canadian Heart Foundation.
      This paper is only available as a PDF. To read, Please Download here.
      The GSR induced by a single injection of endotoxin in pregnant rats and cortisone-sensitized rabbits was prevented by bradykinin. The action is mediated by prostaglandins, such as evidenced by: (1) abolition of the effect of bradykinin by aspirin, (2) prevention of the Shwartzman reaction by infusions of PGA2 and PGE1, and (3) sensitization of the normal male rat to the generalized Shwartzman reaction by indomethacin. The mechanism appears to be a neutralization of the essential α-adrenergic component of the generalized Shwartzman reaction.
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