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The dehydroepiandrosterone loading test

IV. Evaluation of clinical utility
  • Author Footnotes
    * Current address: University of Maryland Hospital, Baltimore, Maryland.
    David A. Nagey
    Correspondence
    Department of Obstetrics and Gynecology, University of Maryland Hospital, 22 South Greene St., Baltimore, Maryland 21201
    Footnotes
    * Current address: University of Maryland Hospital, Baltimore, Maryland.
    Affiliations
    From the Division of Perinatal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina
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  • Author Footnotes
    * Current address: University of Maryland Hospital, Baltimore, Maryland.
    Marcos J. Pupkin
    Footnotes
    * Current address: University of Maryland Hospital, Baltimore, Maryland.
    Affiliations
    From the Division of Perinatal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina
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  • Author Footnotes
    ** Current address: Vanderbilt University Medical Center, Nashville, Tennessee.
    Lisa Mandeville
    Footnotes
    ** Current address: Vanderbilt University Medical Center, Nashville, Tennessee.
    Affiliations
    From the Division of Perinatal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina
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  • David W. Schomberg
    Affiliations
    From the Division of Perinatal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina
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  • Carlyle Crenshaw Jr.
    Correspondence
    Department of Obstetrics and Gynecology, University of Maryland Hospital, 22 South Greene St., Baltimore, Maryland 21201
    Affiliations
    From the Division of Perinatal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina
    Search for articles by this author
  • Author Footnotes
    * Current address: University of Maryland Hospital, Baltimore, Maryland.
    ** Current address: Vanderbilt University Medical Center, Nashville, Tennessee.
      This paper is only available as a PDF. To read, Please Download here.
      This report complements the previously described preliminary clinical evaluation of the dehydroepiandrosterone (DHEA) loading test (DLT) by presenting the results of 65 DLTs in 59 patients. In patients whose fetuses were suspected of being intrauterine growth retarded, a DHEA to estrogen conversion rate constant ≤3.0×10−3 min−1 was associated with a birth weight below the tenth percentile in 60% of the pregnancies, whereas a conversion rate constant above this threshold was not associated with the same degree of growth retardation. The DLT continues to qualify as an accurate predictor of pregnancy outcome as judged by birth weight. Although it seems to be too cumbersome to serve as a screening technique, the DLT will permit evaluation of the efficacy of various pregnancy interventions directed toward improvement of the intrauterine environment, such as bed rest, tocolysis, or antihypertensive medication.
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