Advertisement

Functional and biochemical aspects of laminaria use in first-trimester pregnancy termination

  • Author Footnotes
    * International Exchange Fellow, Department of Obstetrics and Gynecology, Wenzhou Medical College, Wenzhou Zhejiang, People’s Republic of China.
    B.L. Ye
    Footnotes
    * International Exchange Fellow, Department of Obstetrics and Gynecology, Wenzhou Medical College, Wenzhou Zhejiang, People’s Republic of China.
    Affiliations
    From the Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
    Search for articles by this author
  • K. Yamamoto
    Affiliations
    From the Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
    Search for articles by this author
  • J.E. Tyson
    Correspondence
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Manitoba, 59 Emily St., Winnipeg, Manitoba, Canada R3E OW3
    Affiliations
    From the Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
    Search for articles by this author
  • Author Footnotes
    * International Exchange Fellow, Department of Obstetrics and Gynecology, Wenzhou Medical College, Wenzhou Zhejiang, People’s Republic of China.
      This paper is only available as a PDF. To read, Please Download here.
      The effect of laminaria-induced cervical dilatation on plasma levels of the prostaglandin metabolite 13, 14-dihydro-15-keto prostaglandin (PGFM) was evaluated in women undergoing elective first-trimester pregnancy termination. Seventy-one women were randomly assigned to either a treatment (n=45) or control (n=26) group. Cervical dilatation measured at the time of insertion of the laminaria was 3.0±0.1 mm compared to 10.2±0.2 mm at the time of removal of the laminaria 14 to 16 hours later (p<0.001). Peripheral levels of PGFM rose from 28.3±2.4 pg/ml (mean±SEM) to 43.0±2.6 pg/ml at the time of removal of the laminaria (p<0.001). Peripheral concentrations of PGFM in controls remained unchanged. Peripheral concentrations of PGFM did not correlate with the patient's symptoms. Although the hydrophilic property of laminaria is considered to be the principal mechanism promoting cervical dilatation, laminaria may alter the elaboration, release, or degradation of uterine prostaglandin F. Thus, biochemical as well as mechanical factors may enhance cervical dilatation in laminaria-treated women.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Obstetrics & Gynecology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      REFERENCES

        • Eaton C.J.
        • Cohn F.
        • Bollinger C.C.
        Laminaria tent as a cervical dilator prior to aspiration-type therapeutic abortion.
        Obstet. Gynecol. 1972; 39: 533
        • Newton B.W.
        Laminaria tent: Relic of the past or modern medical device?.
        Am. J. Obstet. Gynecol. 1972; 113: 442
        • Golditch I.M.
        • Glasser M.H.
        The use of laminaria tents for cervical dilatation prior to vacuum aspiration abortion.
        Am. J. Obstet. Gynecol. 1974; 119: 481
        • Aiu P.
        • Berman R.
        • Krieger J.
        • et al.
        Laminaria: An underutilized clinical adjunct.
        Clin. Obstet. Gynecol. 1972;
        • Stubblefield P.G.
        • Naftolin F.
        • Erigoletto F.
        • Ryan K.J.
        Laminaria augmentation of intra-amniotic PGF for midtrimester pregnancy termination.
        Prostaglandins. 1975; 10: 413
        • Duenhoelter J.H.
        • Gant N.F.
        • Jimenez J.M.
        Concurrent use of prostaglandin F and laminaria tents for induction of midtrimester abortion.
        Obstet. Gynecol. 1976; 47: 469
        • Hachamovitch M.
        • Bracken M.B.
        • Simons H.
        Saline-instillation abortion with laminaria and megadose oxytocin.
        Am. J. Obstet. Gynecol. 1979; 135: 327
        • Cross W.G.
        • Pitkin R.M.
        Laminaria as an adjunct in induction of labor.
        Obstet. Gynecol. 1978; 51: 606
        • Tohan N.
        • Tejani N.A.
        • Varanasi M.
        • Robins J.
        Ripening of the term cervix with laminaria.
        Obstet. Gynecol. 1979; 54: 588
        • Manabe Y.
        Laminaria tent for gradual and safe cervical dilatation.
        Am. J. Obstet. Gynecol. 1971; 110: 743
        • Ghodgaonkar R.B.
        • Dubin N.H.
        • Blake D.A.
        • King T.M.
        13,14-Dihydro-l5-keto-prostaglandin F concentrations in human plasma and amniotic fluid.
        Am. J. Obstet. Gynecol. 1979; 134: 265
        • MacDonald P.C.
        • Porter J.C.
        • Schwartz B.E.
        • Johnston J.M.
        Initiation of parturition in the human female.
        Semin. Perinatol. 1978; 2: 273
        • Dubin N.H.
        • Johnson J.W.C.
        • Calhoun S.
        • et al.
        Plasma prostaglandin in pregnant women with term and preterm deliveries.
        Obstet. Gynecol. 1981; 57: 203
        • Olsen C.E.
        • Nielsen H.B.
        • Ostergaard E.
        Complications to therapeutic abortions.
        Int. J. Gynaecol. Obstet. 1970; 8: 823
        • Gusdon J.P.
        • May W.J.
        Complications caused by difficult removal of laminaria tents.
        Am. J. Obstet. Gynecol. 1975; 121: 286
        • Jurukovski J.
        • Sukaroy L.
        A critical review of legal abortion.
        Int. J. Gynaecol. Obstet. 1971; 9: 111
        • Chaudhuri G.
        Intrauterine device: Possible role of prostaglandins.
        Lancet. 1971; 1: 480
        • Marx J.L.
        Dysmenorrhea: Basic research leads to a rational therapy.
        Science. 1979; 205: 175
        • Willman E.A.
        • Collins W.P.
        • Clayton S.G.
        Studies in the involvement of prostaglandins in uterine symptomatology and pathology.
        Br. J. Obstet. Gynaecol. 1976; 83: 337