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Research Article| Volume 103, ISSUE 4, P504-510, 1969

The effect of pretreatment with hyperbaric oxygen on the response to anoxia and survival on resuscitation in newborn rabbits

  • Author Footnotes
    * R. S. McLaughlin Travelling Fellozv. Present address: Department of Obstetrics and Gynecology, Women's College Hospital, Toronto, Ontario.
    J.E. Milligan
    Footnotes
    * R. S. McLaughlin Travelling Fellozv. Present address: Department of Obstetrics and Gynecology, Women's College Hospital, Toronto, Ontario.
    Affiliations
    Nuffield Institute for Medical Research, University of Oxford, Toronto, Ontario
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  • Author Footnotes
    ** On leave. Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut. Recipient of United States Public Health Service Career Development Award 5K3HE 18438.
    N.S. Talner
    Footnotes
    ** On leave. Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut. Recipient of United States Public Health Service Career Development Award 5K3HE 18438.
    Affiliations
    Nuffield Institute for Medical Research, University of Oxford, Toronto, Ontario
    Search for articles by this author
  • Author Footnotes
    * R. S. McLaughlin Travelling Fellozv. Present address: Department of Obstetrics and Gynecology, Women's College Hospital, Toronto, Ontario.
    ** On leave. Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut. Recipient of United States Public Health Service Career Development Award 5K3HE 18438.
DOI:https://doi.org/10.1016/S0002-9378(15)31852-4
The effect of pretreatment with hyperbaric oxygen on the response to anoxia and survival on resuscitation in newborn rabbits
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      The effect of pretreatment with hyperbaric oxygen on the response to anoxia and survival on resuscitation was studied in newborn rabbits less than 48 hours of age. The over-all pattern of reaction to anoxia and the time to last gasp were similar in rabbits pretreated with hyperbaric oxygen and controls. However, a comparison of survival rates on resuscitation during secondary apnea revealed that the group treated with hyperbaric oxygen had a significantly lower rate of survival than the control rabbits. This adverse effect on survival was prevented by the prior administration of sedating doses of pentobarbital. It was also noted that pentobarbital administered in sedating doses prolonged the time of primary apnea and the time to last gasp in rabbits so treated. However, it did not increase survival on resuscitation in secondary apnea over that found in the control animals.
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      Article info

      Footnotes

      Presented by invitation at the Twenty-fourth Annual Meeting of the Society of Obstetricians and Gynaecologists of Canada, The Chanticler, St. Adèle, Quebec, June 14–16, 1968.

      Identification

      DOI: https://doi.org/10.1016/S0002-9378(15)31852-4

      Copyright

      © 1969 The C. V. Mosby Company. Published by Elsevier Inc. All rights reserved.

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