Objective
Women with a history of preeclampsia are at increased lifetime risk for cardiovascular
disease. Their offspring may carry similar risks. The aim was to study cardiovascular
and metabolic risk factors 11 years after the delivery among women who were diagnosed
with mild, moderate, or severe preeclampsia, and their offspring, compared with women
without preeclampsia and their offspring.
Study Design
In a follow-up 11 years after a nested case-control study at birth, we studied 611
mother-offspring dyads, including 228 dyads with preeclampsia in the index pregnancy
and 383 dyads without preeclampsia. Cardiovascular and metabolic risk profiles were assessed
by serum lipids (total cholesterol, high-density lipoprotein [HDL] cholesterol, non-HDL
cholesterol), insulin-related factors (glucose, insulin, and homeostasis assessment
model for insulin resistance) and blood pressure in mothers and children.
Results
Among mothers with mild or moderate preeclampsia, levels of glucose, insulin, and
homeostasis assessment model for insulin resistance were higher than in the nonpreeclampsia
group and also higher compared with mothers with severe preeclampsia (all P < .05). HDL cholesterol was lower in mothers with mild or moderate preeclampsia (all
P < .05), but other lipids did not substantially differ between the groups. Body mass
index and blood pressure (systolic and diastolic) were also higher in the mild and
moderate preeclampsia group compared with mothers without preeclampsia (all P < .05). Among the offspring, we found no clear differences in any blood analytes
between the groups.
Conclusion
Women with a previous diagnosis of mild or moderate, but not severe, preeclampsia
may have an adverse metabolic and cardiovascular risk profile 11 years after the delivery.
Key words
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Article Info
Publication History
Published online: June 17, 2014
Accepted:
June 11,
2014
Received in revised form:
April 23,
2014
Received:
February 6,
2014
Footnotes
The authors report no conflict of interest.
Cite this article as: Alsnes IV, Janszky I, Forman MR, et al. A population-based study of associations between preeclampsia and later cardiovascular risk factors. Am J Obstet Gynecol 2014;211:657.e1-7.
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
