To determine the prevalence of dyslipidemia in postpartum women diagnosed with gestational diabetes mellitus (GDM) and to evaluate the impact of Body Mass Index (BMI) on the presence of dyslipidemia.
A prospective cohort study comprising patients diagnosed with GDM was performed. A fasting lipid profile was analyzed at 6 weeks postpartum. Dyslipidemia was defined as having at least one of the following: raised total cholesterol, raised low-density lipoprotein (LDL), decreased high-density lipoprotein (HDL) or raised triglycerides. The prevalence of dyslipidemia was compared across BMI categories.
Of 82 patients participating in the study 63.4% (52/82) had an abnormal fasting lipid profile at 6 weeks postpartum. The average age of the study population was 33.0 years. The prevalence of dyslipidemia increased significantly with increasing BMI from 50% in women with a normal BMI to 89% in those with class II-III obesity (p=0.03 , OR: 1.78). Raised total cholesterol and raised LDL were the most common forms of dyslipidemia occurring in 56% and 41% of the population respectively.
Women diagnosed with GDM are at high risk of dyslipidemia. This risk increases with increasing BMI category. Other studies have shown that women with GDM have an increased risk of developing type II diabetes mellitus and an increased risk of developing cardiovascular disease independent of type II diabetes mellitus. Dyslipidemia, an important risk factor for cardiovascular disease, is already highly prevalent in women with GDM at a young age. Awareness of, and investigation for, this potentially modifiable risk factor is important. All patients with GDM should have a fasting lipid profile performed postnatally as well as a full assessment of cardiovascular risk.
© 2013 Mosby, Inc. Published by Elsevier Inc. All rights reserved.