Objective
The purpose of this study was to evaluate the performance of the 12-hour urine protein
>165 mg and protein:creatinine ratio >0.15 for the prediction of 24-hour urine protein
of ≥300 mg in patients with suspected preeclampsia.
Study Design
We performed a prospective observational study of 90 women who had been admitted with
suspected preeclampsia. Protein:creatinine ratio and 12- and 24-hour urine specimens
were collected for each patient. Test characteristics for the identification of 24-hour
urine protein ≥300 mg were calculated.
Results
A 12-hour urine protein >165 mg and protein:creatinine ratio of >0.15 correlated significantly
with 24-hour urine protein ≥300 mg (r = 0.99; P < .001; and r = 0.54; P < .001, respectively). A 12-hour urine protein >165 mg performed better than protein:creatinine
ratio as a predictor of a 24-hour urine protein ≥300 mg (sensitivity, 96% and 89%;
specificity, 100% and 49%; positive predictive value, 100% and 32%; negative predictive
value, 98% and 91%, respectively).
Conclusion
The high correlation of a 12-hour urine protein >165 mg with a 24-hour urine protein
≥300 mg (with the benefit of a shorter evaluation time) and the high negative predictive
value of protein:creatinine ratio suggest that the use of both these tests have a
role in the evaluation and treatment of women with suspected preeclampsia.
Key words
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Article info
Publication history
Published online: June 13, 2012
Accepted:
June 5,
2012
Received in revised form:
May 5,
2012
Received:
March 13,
2012
Footnotes
Supported by the Lehigh Valley Health Network Department of Obstetrics and Gynecology Research Fund.
The authors report no conflict of interest.
Reprints not available from the authors.
Cite this article as: Tun C, Quiñones JN, Kurt A, et al. Comparison of 12-hour urine protein and protein:creatinine ratio with 24-hour urine protein for the diagnosis of preeclampsia. Am J Obstet Gynecol 2012;207:233.e1-8.
Identification
Copyright
© 2012 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
