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Research Article| Volume 164, ISSUE 2, P482-485, February 1991

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The effects of iodoprophylaxis on thyroid size during pregnancy

  • Author Footnotes
    a From the Departments of Internal Medicine, University of L’Aquila.
    ,
    Author Footnotes
    * Recipient of a Fellowship from the PhD course in endocrinology at the University of L’Aquila.
    Rossella Romano
    Footnotes
    a From the Departments of Internal Medicine, University of L’Aquila.
    * Recipient of a Fellowship from the PhD course in endocrinology at the University of L’Aquila.
    Affiliations
    L’Aquila, Italy
    Search for articles by this author
  • Author Footnotes
    b Department of Experimental Medicine, University of L’Aquila.
    ,
    Author Footnotes
    * Recipient of a Fellowship from the PhD course in endocrinology at the University of L’Aquila.
    Emmanuele A. Jannini
    Footnotes
    b Department of Experimental Medicine, University of L’Aquila.
    * Recipient of a Fellowship from the PhD course in endocrinology at the University of L’Aquila.
    Affiliations
    L’Aquila, Italy
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  • Author Footnotes
    b Department of Experimental Medicine, University of L’Aquila.
    Mario Pepe
    Footnotes
    b Department of Experimental Medicine, University of L’Aquila.
    Affiliations
    L’Aquila, Italy
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  • Author Footnotes
    b Department of Experimental Medicine, University of L’Aquila.
    Alessandro Grimaldi
    Footnotes
    b Department of Experimental Medicine, University of L’Aquila.
    Affiliations
    L’Aquila, Italy
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  • Author Footnotes
    b Department of Experimental Medicine, University of L’Aquila.
    Michele Olivieri
    Footnotes
    b Department of Experimental Medicine, University of L’Aquila.
    Affiliations
    L’Aquila, Italy
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  • Author Footnotes
    b Department of Experimental Medicine, University of L’Aquila.
    Patrizia Spennati
    Footnotes
    b Department of Experimental Medicine, University of L’Aquila.
    Affiliations
    L’Aquila, Italy
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  • Author Footnotes
    c Department of Surgery, University of L’Aquila.
    Francesco Cappa
    Footnotes
    c Department of Surgery, University of L’Aquila.
    Affiliations
    L’Aquila, Italy
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  • Author Footnotes
    b Department of Experimental Medicine, University of L’Aquila.
    Massimino D’Armiento
    Correspondence
    Reprint requests: Massimino D’Armiento, MD, Division of Endocrinology, Department of Experimental Medicine, University of L’Aquila, Collemaggio, L’Aquila, Italy 67100.
    Footnotes
    b Department of Experimental Medicine, University of L’Aquila.
    Affiliations
    L’Aquila, Italy
    Search for articles by this author
  • Author Footnotes
    a From the Departments of Internal Medicine, University of L’Aquila.
    b Department of Experimental Medicine, University of L’Aquila.
    c Department of Surgery, University of L’Aquila.
    * Recipient of a Fellowship from the PhD course in endocrinology at the University of L’Aquila.
DOI:https://doi.org/10.1016/S0002-9378(11)80004-9
The effects of iodoprophylaxis on thyroid size during pregnancy
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      Thyroid gland size was ultrasonographically determined in 35 pregnant women who live in an area with moderate iodine deficiency. Iodide salt was administered to group A (n = 17), whereas group B (n = 18) was used as a control. Each group was tested for thyroid-stimulating hormone serum levels, iodine excretion, and thyroid volume. In both groups thyroid-stimulating hormone levels were similar and did not change throughout pregnancy. The iodine excretion at the third trimester in the treated group was significantly (p < 0.01) higher than that of group B (100.0 ± 39.0 versus 50.0 ± 37.0 fig iodine per 24 hours, respectively). Initially, thyroid volume did not differ between the two groups. At the end of pregnancy, no difference was found in thyroid size in group A, whereas in the untreated women it increased significantly (p < 0.0001) with a mean increase of 1.6 ± 0.6 ml (16.2% ± 6.0%). These results show that the increased thyroid size in the control group was mainly a result of relative iodine deficiency and that iodoprophylaxis should be warranted even in areas with moderate iodine deficiency to prevent the increase in thyroid size and, probably, to avoid the risk of maternal and fetal hypothyroidism.

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      Article info

      Publication history

      Accepted: September 19, 1990
      Received in revised form: September 7, 1990
      Received: June 27, 1990

      Footnotes

      1Supported by a grant from the Italian Ministry of Health.

      Identification

      DOI: https://doi.org/10.1016/S0002-9378(11)80004-9

      Copyright

      © 1991 Mosby. Published by Elsevier Inc. All rights reserved.

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