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Obstructive sleep apnea and the risk of adverse pregnancy outcomes

Published:September 16, 2011DOI:https://doi.org/10.1016/j.ajog.2011.09.006

      Objective

      We examined the risk of adverse pregnancy outcomes, including low birthweight (LBW), preterm birth, small for gestational age (SGA), cesarean section (CS), low Apgar score (at 5 minutes after delivery), and preeclampsia in pregnant women with and without obstructive sleep apnea (OSA).

      Study Design

      Our subjects included 791 women with OSA and 3955 randomly selected women without OSA. We performed conditional logistic regression analyses to examine the risks of adverse pregnancy outcomes between women with and without OSA.

      Results

      Compared with women without OSA, adjusted odds ratios for LBW, preterm birth, SGA infants, CS, and preeclampsia in women with OSA were 1.76 (95% confidence interval [CI], 1.28–2.40), 2.31 (95% CI, 1.77–3.01), 1.34 (95% CI, 1.09–1.66), 1.74 (95% CI, 1.48–2.04), and 1.60 (95% CI, 2.16–11.26), respectively.

      Conclusion

      Pregnant women with OSA are at increased risk for having LBW, preterm, and SGA infants, CS, and preeclampsia, compared with pregnant women without OSA.

      Key words

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      Linked Article

      • Discussion: ‘Sleep apnea and adverse pregnancy outcomes’ by Chen et al
        American Journal of Obstetrics & GynecologyVol. 206Issue 2
        • Preview
          In the roundtable that follows, clinicians discuss a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed: Chen Y-H, Kang J-H, Lin C-C, et al. Obstructive sleep apnea and the risk of adverse pregnancy outcomes. Am J Obstet Gynecol 2012;206:136.e1-5.
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