Objective
The purpose of this study was to compare the efficacy of 2 different doses of tinidazole
with metronidazole for the treatment of bacterial vaginosis and to compare the side
effects of the drugs.
Study Design
Women were assigned randomly to receive metronidazole 500 mg twice daily, tinidazole
500 mg twice daily, or tinidazole 1 g twice, all for 7 days. Follow-up visits were
conducted at days 14 and 28.
Results
Five hundred ninety-three women were enrolled. There were no significant differences
between the treatment arms. Overall cure rates were 76.8% at 14 days and 64.5% at
1 month. Women who admitted to engaging in sexual intercourse during the study were
significantly more likely to have bacterial vaginosis at the follow-up visit. There
were no significant differences in adverse events across treatment arms.
Conclusion
There were no differences in cure rates between metronidazole and either of the tinidazole
dosing regimens that were studied. In addition, there were no important differences
in the side-effect profiles of metronidazole and tinidazole.
Key words
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Article info
Publication history
Published online: December 20, 2010
Accepted:
October 11,
2010
Received in revised form:
September 7,
2010
Received:
July 21,
2010
Footnotes
Supported by the National Institutes of Allergy and Infectious Diseases at the National Institutes of Health, Grant no. R01AI058033; tinidazole was provided by Mission Pharmacal Company, San Antonio, TX.
Cite this article as: Schwebke JR, Desmond RA. Tinidazole vs metronidazole for the treatment of bacterial vaginosis. Am J Obstet Gynecol 2011;204:211.e1-6.
Identification
Copyright
© 2011 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
