Fetal exposure to gestational diabetes contributes to subsequent adult metabolic syndrome

Published:April 29, 2010DOI:
      Obesity and diabetes have become globally epidemic. The cause of this unprecedented rise in obesity is multifactorial, with inactivity, excessive calorie intake, and genetic factors implicated. More recent data indicate that exposure to diabetes during pregnancy increases the risk of childhood and adult obesity, diabetes, and cardiovascular disease. Evidence derived from recent randomized controlled trials indicates that gestational diabetes mellitus (GDM) treatment reduces newborn obesity and therefore may contribute to reducing the global prevalence of obesity and metabolic syndrome. Current evidence detailing increases in global prevalence of obesity was reviewed together with data evaluating the effectiveness of treatment of GDM. Development of new protocols for diagnosis and treatment of GDM may reduce population obesity and cardiovascular disease.

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        • Reaven G.M.
        Banting lecture 1988: role of insulin resistance in human disease.
        Diabetes. 1988; 37: 1595-1607
        • Boney C.M.
        • Verma A.
        • Tucker R.
        • et al.
        Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus.
        Pediatrics. 2005; 115: e290-e296
        • Dabelea D.
        • Knowler W.C.
        • Pettitt D.J.
        Effect of diabetes in pregnancy on offspring: follow-up research in the Pima Indians.
        J Matern Fetal Med. 2000; 9: 83-88
      1. WHO fact sheet no. 311. Obesity and overweight.
        (Accessed Dec. 1, 2009)
        • World Health Organization
        Obesity: preventing and managing the global epidemic; report of a WHO consultation.
        WHO technical report series 894. World Health Organization, Geneva2000
        • Ogden C.L.
        • Carroll M.D.
        • Flegal K.M.
        High body mass index for age among US children and adolescents, 2003-2006.
        JAMA. 2008; 299: 2401-2405
        • Wild S.
        • Roglic G.
        • Green A.
        • et al.
        Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.
        Diabetes Care. 2004; 27: 1047-1053
        • National Institute of Diabetes and Digestive and Kidney Diseases
        National diabetes statistics, 2007 fact sheet.
        US Department of Health and Human Services, National Institutes of Health, Bethesda, MD2008
        • Dabelea D.
        • Snell-Bergeon J.K.
        • Hartsfield C.L.
        • et al.
        Increasing prevalence of gestational diabetes mellitus (GDM) over time and by birth cohort: Kaiser Permanente of Colorado GDM screening program.
        Diabetes Care. 2005; 28: 579-584
        • Dabelea D.
        • Hanson R.L.
        • Lindsay R.S.
        • et al.
        Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships.
        Diabetes. 2000; 49: 2208-2211
        • Pettitt D.J.
        • Knowler W.C.
        Long-term effects of the intrauterine environment, birth weight, and breast-feeding in Pima Indians.
        Diabetes Care. 1998; 21: B138-B141
        • Clausen T.D.
        • Mathiesen E.R.
        • Hansen T.
        • et al.
        Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes.
        J Clin Endocrinol Metab. 2009; 94: 2464-2470
        • Hillier T.A.
        • Vesco K.K.
        • Pedula K.L.
        • Beil T.L.
        • Whitlock E.P.
        • Pettitt D.J.
        Screening for gestational diabetes mellitus: a systematic review for the US Preventive Services Task Force.
        Ann Intern Med. 2008; 148: 766-775
        • Crowther C.A.
        • Hiller J.E.
        • Moss J.R.
        • McPhee A.J.
        • Jeffries W.S.
        • Robinson J.S.
        Effect of treatment of gestational diabetes mellitus on pregnancy outcomes.
        N Engl J Med. 2005; 352: 2477-2486
        • Landon M.B.
        • Spong C.Y.
        • Thom E.
        • et al.
        A multicenter, randomized trial of treatment for mild gestational diabetes.
        N Engl J Med. 2009; 361: 1339-1348
        • Williams R.L.
        • Creasy R.K.
        • Cunningham G.C.
        • Hawes W.E.
        • Norris F.D.
        • Tashiro M.
        Fetal growth and perinatal viability in California.
        Obstet Gynecol. 1982; 59: 624-632
        • Pirc L.K.
        • Owens J.A.
        • Crowther C.A.
        • Willson K.
        • De Blasio M.J.
        • Robinson J.S.
        Mild gestational diabetes in pregnancy and the adipoinsular axis in babies born to mothers in the ACHOIS randomized controlled trial.
        BMC Pediatr. 2007; 7: 18
        • Metzger B.E.
        • Lowe L.P.
        • Dyer A.R.
        • et al.
        Hyperglycemia and adverse pregnancy outcomes.
        N Engl J Med. 2008; 358: 1991-2002