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Poster session IV Academic issues, epidemiology, global maternal-fetal public health, infectious diseases, intrapartum fetal assessment, operative obstetrics| Volume 201, ISSUE 6, SUPPLEMENT , S234-S235, December 01, 2009

645: A linear association exists between the location of GBS colonization and adverse pregnancy outcomes

      Objective

      To investigate pregnancy outcomes in patients with group-B streptococcus (GBS) colonization (in urine or vaginal cultures). We hypothesized that the highest risk for adverse perinatal outcomes, such as premature rupture of membranes (PROM) and preterm delivery, would be found for the urine positive GBS group (U-GBS), moderate risk would be found in the vaginal positive GBS group (V-GBS) and the lowest risk for those without GBS colonization.

      Study Design

      A retrospective study comparing pregnancy outcomes of women who were positive for GBS in urine cultures, positive for GBS in vaginal cultures as compared to those without GBS colonization during pregnancy, was conducted. The Linear by Linear association chi-square test for differences in qualitative variables and the t-test for differences in continuous variables were used.

      Results

      A significant linear association was documented between the three groups and adverse outcomes (table).
      Tabled 1Selected pregnancy and perinatal outcomes (%) in patients with U-GBS, V-GBS and those with no GBS colonization
      CharacteristicsU-GBS (n=1805)V-GBS (n=1867)No GBS (n=180,594)P-value (Linear by Linear)
      Recurrent abortions6.65.95.40.014
      Cervical os incontinence1.30.70.5<0.001
      Pregestational diabetes8.86.96.7<0.001
      Preterm contractions1.30.30.4<0.001
      PROM9.89.86.8<0.001
      Preterm delivery15.86.57.8<0.001
      Chorioamnionitis3.81.20.8<0.001
      Intrapartum fever0.40.20.1<0.001

      Conclusion

      Women positive for GBS are at increased risk for adverse obstetric outcomes, while the risk is higher for patients positive for GBS in urine cultures as compared to those positive in vaginal cultures.