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292: First trimester placental growth factor - Relationship with maternal factors and placental development

      Objective

      Placental growth factor (PIGF) is a potent angiogenic factor that impacts early placental vascular development. It was our aim to clarify relationships between PIGF and first trimester maternal/placental factors that are related to placental development.

      Study Design

      Prospectively enrolled patients at 11-14 weeks had serum PIGF measurement by ELISA. Results were related to maternal age, parity, race, body mass index (BMI), mean arterial blood pressure (MAP), smoking/caffeine use and parameters of placental blood flow resistance.

      Results

      In 111 consecutive patients PIGF levels ranged between 1.0-176.1 picogram/ml showing a linear relationship with gestational age (PIGF= 1.4251GA - 74.951, R2 =0.0765, F 8.941, p=0.003 figure). PIGF did not relate to maternal demographics but negatively correlated with MAP (Pearsons=-0.191, p<0.05). Bilateral uterine artery notching was associated with lower PIGF (40.7 pg/ml (1.01-131.6) vs 51.1 pg/ml (6.4-170.1; Mann Whitney p<0.05.). A trend to lower levels was also observed when umbilical artery end-diastolic flow was absent (37.1 pg/ml (6.8-95) vs. 49.3 pg/ml (1.01-176.6; p=0.05).

      Conclusion

      Placental growth factor in the first trimester is related to maternal cardiovascular factors and placental Doppler findings that are associated with subsequent placental dysfunction. The utility of this parameter as a first trimester screening tool merits further investigation.