269: Prediction of cardiovascular risk disease in neonate born because of IUGR after a follow up of 18 months


      Several studies emphasized that IUGR fetuses have an increased risk of cardiovascular disease in adulthood. Aortic intima media thickness (aIMT) is significantly higher in IUGR fetuses than in AGA fetuses. This finding suggests that several conditions are involved to a persistently increased cardiovascular risk in adulthood.
      The aim of this prospective study was twofold: to measure the aIMT in neonate that were IUGR after 18 moths of birth and compare the values of aIMT previously measured during gestation and to evaluate the measurements of arterial blood pressure and urinary Albumin/Creatinine Ratio (ACR), which are considered feasible markers of cardiovascular risk in neonate that were IUGR

      Study Design

      In all neonates, aIMT was measured, by high-resolution ultrasound scan, in the dorsal arterial wall of the abdominal aorta. Anthropometric parameters and blood pressure were recorded as well as a urine sample was taken to dose Microalbumin and Creatinine.
      Data were compared using Mann-Whitney test. The Spearman′s rank correlation was used to correlate aIMT and other parameters


      Twenty four neonates were enrolled in the present prospective longitudinal study, 11 were IUGR and 13 AGA fetuses. Mean age of the study group was 18 months (range 10-24 months). The aIMT was significantly higher in neonates that were IUGR both before and after birth (p<.001, p<.001, respectively). Systolic Blood Pressure was significantly increased in IUGR children (p=.03) as well as ACR (p=0.05)


      In neonates born because of IUGR after a follow up of 18 months, show values of aIMT, systolic blood pressure and ACR significantly higher than controls. The increased cardiovascular risk does not decrease during the first 18 months of life. Furthermore, the damage of vascular walls seems to progress during the first months of life, as suggested by the increase of systolic blood pressure and ACR