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Preeclampsia and subsequent risk of cancer: update from the Jerusalem Perinatal Study

Published:September 26, 2008DOI:https://doi.org/10.1016/j.ajog.2008.06.057

      Objective

      The purpose of this study was to examine the association between preeclampsia and cancer incidence.

      Study Design

      The Jerusalem Perinatal Study is a population-based cohort of all births to 41,206 residents of Western Jerusalem from 1964-76. Cancer incidence to 2004 was assessed by linkage of the cohort with the Israel Cancer Registry. Cox's proportional hazards models were constructed to estimate the hazard ratio for cancer among women who had had preeclampsia.

      Results

      Preeclampsia was associated with a 1.23-fold increased risk of cancer at all sites, a 37% increased risk of breast cancer, and more than a doubling of ovarian cancer risk. Analysis by morphologic condition yielded significantly increased risks for malignancies that were classed as cystic mucinous and serous (relative risk, 1.96; 95% CI, 1.00-3.83) and for ductal, lobular, and medullary carcinomas (relative risk, 1.40; 95% CI, 1.07-1.83). No differential association was observed by sex of offspring.

      Conclusion

      Our study suggests that the previously described protective effect of preeclampsia on cancer is not universal.

      Key words

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      References

        • Terry M.B.
        • Perrin M.
        • Salafia C.M.
        • et al.
        Preeclampsia, pregnancy-related hypertension, and breast cancer risk.
        Am J Epidemiol. 2007; 165: 1007-1014
        • Innes K.E.
        • Byers T.E.
        First pregnancy characteristics and subsequent breast cancer risk among young women.
        Int J Cancer. 2004; 112: 306-311
        • Polednak A.P.
        • Janerich D.T.
        Characteristics of first pregnancy in relation to early breast cancer: a case-control study.
        J Reprod Med. 1983; 28: 314-318
        • Troisi R.
        • Weiss H.A.
        • Hoover R.N.
        • et al.
        Pregnancy characteristics and maternal risk of breast cancer.
        Epidemiology. 1998; 9: 641-647
        • Vatten L.J.
        • Romundstad P.R.
        • Trichopoulos D.
        • Skjaerven R.
        Pre-eclampsia in pregnancy and subsequent risk for breast cancer.
        Br J Cancer. 2002; 87: 971-973
        • Troisi R.
        • Innes K.E.
        • Roberts J.M.
        • Hoover R.N.
        Preeclampsia and maternal breast cancer risk by offspring gender: do elevated androgen concentrations play a role?.
        Br J Cancer. 2007; 97: 688-690
        • Vatten L.J.
        • Forman M.R.
        • Nilsen T.I.
        • Barrett J.C.
        • Romundstad P.R.
        The negative association between pre-eclampsia and breast cancer risk may depend on the offspring's gender.
        Br J Cancer. 2007; 96: 1436-1438
        • Irgens H.U.
        • Reisaeter L.
        • Irgens L.M.
        • Lie R.T.
        Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study.
        BMJ. 2001; 323: 1213-1217
        • Aagaard-Tillery K.M.
        • Stoddard G.J.
        • Holmgren C.
        • et al.
        Preeclampsia and subsequent risk of cancer in Utah.
        Am J Obstet Gynecol. 2006; 195: 691-699
        • Paltiel O.
        • Friedlander Y.
        • Tiram E.
        • Barchana M.
        • Xue X.
        • Harlap S.
        Cancer after pre-eclampsia: follow up of the Jerusalem perinatal study cohort.
        BMJ. 2004; 328: 919
        • Harlap S.
        • Davies A.M.
        • Deutsch L.
        • et al.
        The Jerusalem Perinatal Study cohort, 1964-2005: methods and a review of the main results.
        Paediatr Perinat Epidemiol. 2007; 21: 256-273
        • Richardson B.E.
        • Peck J.D.
        • Wormuth J.K.
        Mean arterial pressure, pregnancy-induced hypertension, and preeclampsia: evaluation as independent risk factors and as surrogates for high maternal serum alpha-fetoprotein in estimating breast cancer risk.
        Cancer Epidemiol Biomarkers Prev. 2000; 9: 1349-1355
        • Lynch H.T.
        • Rubinstein W.S.
        • Locker G.Y.
        Cancer in Jews: introduction and overview.
        Fam Cancer. 2004; 3: 177-192
      1. Israel Cancer Registry, Ministry of Health. Cancer incidence in Israel by age and country of birth, 2001 - breast and ovary. Available at: http://heath.gov.il/download/sartan/2001/Breast2.xls and http://www.heath.gov.il/download/sartan/2001/ovary2.xls. Accessed July 28, 2008.

        • King M.C.
        • Marks J.H.
        • Mandell J.B.
        Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2.
        Science. 2003; 302: 643-646
        • Calderon-Margalit R.
        • Paltiel O.
        Prevention of breast cancer in women who carry BRCA1 or BRCA2 mutations: a critical review of the literature.
        Int J Cancer. 2004; 112: 357-364
        • Weiss-Salz I.
        • Harlap S.
        • Friedlander Y.
        • et al.
        Ethnic ancestry and increased paternal age are risk factors for breast cancer before the age of 40 years.
        Eur J Cancer Prev. 2007; 16: 549-554