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Clinical opinion Obstetrics| Volume 200, ISSUE 4, P365.e1-365.e8, April 2009

Preventing type 2 diabetes: public health implications for women with a history of gestational diabetes mellitus

Published:August 11, 2008DOI:https://doi.org/10.1016/j.ajog.2008.06.031
      There is now strong evidence that lifestyle modification can prevent or delay the development of type 2 diabetes mellitus in high-risk individuals. Women with gestational diabetes mellitus are at increased risk for type 2 diabetes and so are candidates for prevention programs. We review literature on type 2 diabetes risk in women with gestational diabetes, examine current recommendations for postpartum and long-term follow-up, and summarize findings from a 2007 expert-panel meeting. We found data to support that women with gestational diabetes have an increase in risk of type 2 diabetes comparable in magnitude with that of individuals with impaired glucose tolerance and/or impaired fasting glucose and that prevention interventions likely are effective in this population. Current recommendations from leading organizations on follow-up of women after delivery are conflicting and compliance is poor. Clinicians and public health workers face numerous challenges in developing intervention strategies for this population. Translation research will be critical in addressing this important public health issue.

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      References

        • Wild S.
        • Roglic G.
        • Green A.
        • Sicree R.
        • King H.
        Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.
        Diabetes Care. 2004; 27: 1047-1053
        • Yach D.
        • Stuckler D.
        • Brownell K.D.
        Epidemiologic and economic consequences of the global epidemics of obesity and diabetes.
        Nat Med. 2006; 12: 62-66
        • King H.
        • Aubert R.E.
        • Herman W.H.
        Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections.
        Diabetes Care. 1998; 21: 1414-1431
        • Gillies C.L.
        • Abrams K.R.
        • Lambert P.C.
        • et al.
        Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis.
        BMJ. 2007; 334: 299
        • Oldroyd J.C.
        • Unwin N.C.
        • White M.
        • Mathers J.C.
        • Alberti K.G.
        Randomised controlled trial evaluating lifestyle interventions in people with impaired glucose tolerance.
        Diabetes Res Clin Pract. 2006; 72: 117-127
        • Nathan D.M.
        • Davidson M.B.
        • DeFronzo R.A.
        • et al.
        Impaired fasting glucose and impaired glucose tolerance: implications for care.
        Diabetes Care. 2007; 30: 753-759
        • Chiasson J.L.
        • Josse R.G.
        • Gomis R.
        • Hanefeld M.
        • Karasik A.
        • Laakso M.
        Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial.
        Lancet. 2002; 359: 2072-2077
        • Buchanan T.A.
        • Xiang A.H.
        • Peters R.K.
        • et al.
        Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk Hispanic women.
        Diabetes. 2002; 51: 2796-2803
        • Buchanan T.A.
        Pancreatic beta-cell loss and preservation in type 2 diabetes.
        Clin Ther. 2003; 25: B32-B46
        • Knowler W.C.
        • Barrett-Connor E.
        • Fowler S.E.
        • et al.
        Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
        N Engl J Med. 2002; 346: 393-403
        • Pan X.R.
        • Li G.W.
        • Hu Y.H.
        • et al.
        Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance.
        Diabetes Care. 1997; 20: 537-544
        • Ramachandran A.
        • Snehalatha C.
        • Mary S.
        • Mukesh B.
        • Bhaskar A.D.
        • Vijay V.
        The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1).
        Diabetologia. 2006; 49: 289-297
        • Xiang A.H.
        • Peters R.K.
        • Kjos S.L.
        • et al.
        Effect of pioglitazone on pancreatic beta-cell function and diabetes risk in Hispanic women with prior gestational diabetes.
        Diabetes. 2006; 55: 517-522
        • Torgerson J.S.
        • Hauptman J.
        • Boldrin M.N.
        • Sjostrom L.
        XENical in the Prevention of Diabetes in Obese Subjects (XENDOS) Study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients.
        Diabetes Care. 2004; 27: 155-161
        • Tuomilehto J.
        • Lindstrom J.
        • Eriksson J.G.
        • et al.
        Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.
        N Engl J Med. 2001; 344: 1343-1350
        • Buchanan T.A.
        • Xiang A.H.
        Gestational diabetes mellitus.
        J Clin Invest. 2005; 115: 485-491
        • Engelgau M.M.
        • Colagiuri S.
        • Ramachandran A.
        • Borch-Johnsen K.
        • Narayan K.M.
        Prevention of type 2 diabetes: issues and strategies for identifying persons for interventions.
        Diabetes Technol Ther. 2004; 6: 874-882
        • US Preventive Services Task Force
        Screening for type 2 diabetes mellitus in adults: Recommendations and rationale.
        Ann Intern Med. 2003; 138: 212-214
        • Hunt K.J.
        • Schuller K.L.
        The increasing prevalence of diabetes in pregnancy.
        Obstet Gynecol Clin North Am. 2007; 34: 173-199
        • Kaaja R.J.
        • Greer I.A.
        Manifestations of chronic disease during pregnancy.
        JAMA. 2005; 294: 2751-2757
        • Buchanan T.A.
        • Xiang A.H.
        Gestational diabetes mellitus.
        J Clin Invest. 2005; 115: 485-491
        • Russell M.A.
        • Phipps M.G.
        • Olson C.L.
        • Welch H.G.
        • Carpenter M.W.
        Rates of postpartum glucose testing after gestational diabetes mellitus.
        Obstet Gynecol. 2006; 108: 1456-1462
        • Kim C.
        • Tabaei B.P.
        • Burke R.
        • et al.
        Missed opportunities for type 2 diabetes mellitus screening among women with a history of gestational diabetes mellitus.
        Am J Public Health. 2006; 96: 1643-1648
        • Smirnakis K.V.
        • Chasan-Taber L.
        • Wolf M.
        • Markenson G.
        • Ecker J.L.
        • Thadhani R.
        Postpartum diabetes screening in women with a history of gestational diabetes.
        Obstet Gynecol. 2005; 106: 1297-1303
        • Schaefer-Graf U.M.
        • Buchanan T.A.
        • Xiang A.H.
        • Peters R.K.
        • Kjos S.L.
        Clinical predictors for a high risk for the development of diabetes mellitus in the early puerperium in women with recent gestational diabetes mellitus.
        Am J Obstet Gynecol. 2002; 186: 751-756
        • Conway D.L.
        • Langer O.
        Effects of new criteria for type 2 diabetes on the rate of postpartum glucose intolerance in women with gestational diabetes.
        Am J Obstet Gynecol. 1999; 181: 610-614
        • Albareda M.
        Diabetes and abnormal glucose tolerance in women with previous gestational diabetes.
        Diabetes Care. 2003; 26: 1199-1205
        • Lee A.J.
        • Hiscock R.J.
        • Wein P.
        • Walker S.P.
        • Permezel M.
        Gestational diabetes mellitus: clinical predictors and long-term risk of developing type 2 diabetes: a retrospective cohort study using survival analysis.
        Diabetes Care. 2007; 30: 878-883
        • Kim C.
        • Newton K.M.
        • Knopp R.H.
        Gestational diabetes and the incidence of type 2 diabetes: a systematic review.
        Diabetes Care. 2002; 25: 1862-1868
      1. Centers for Disease Control and Prevention, National Center for Health Statistics, Division of Health Interview Statistics.
        (Accessed Sept. 4, 2007)
        • Oldfield M.D.
        • Donley P.
        • Walwyn L.
        • Scudamore I.
        • Gregory R.
        Long term prognosis of women with gestational diabetes in a multiethnic population.
        Postgrad Med J. 2007; 83: 426-430
        • Kousta E.
        • Lawrence N.J.
        • Godsland I.F.
        • et al.
        Insulin resistance and beta-cell dysfunction in normoglycaemic European women with a history of gestational diabetes.
        Clin Endocrinol (Oxf). 2003; 59: 289-297
        • Kousta E.
        • Efstathiadou Z.
        • Lawrence N.J.
        • et al.
        The impact of ethnicity on glucose regulation and the metabolic syndrome following gestational diabetes.
        Diabetologia. 2006; 49: 36-40
        • Kjos S.L.
        • Peters R.K.
        • Xiang A.
        • Henry O.A.
        • Montoro M.
        • Buchanan T.A.
        Predicting future diabetes in Latino women with gestational diabetes.
        Diabetes. 1995; 44: 586-591
        • Ben-Haroush A.
        • Yogev Y.
        • Hod M.
        Epidemiology of gestational diabetes mellitus and its association with type 2 diabetes.
        Diabet Med. 2004; 21: 103-113
        • Hanson U.
        Increased molar proinsulin-to-insulin ratio in women with previous gestational diabetes does not predict later impairment of glucose tolerance.
        Diabetes Care. 1996; 19: 17-20
        • Aberg A.E.
        Predictive factors of developing diabetes mellitus in women with gestational diabetes.
        Acta Obstet Gynecol Scand. 2002; 81: 11-16
        • Benjamin E.
        • Winters D.
        • Mayfield J.
        • Gohdes D.
        Diabetes in pregnancy in Zuni Indian women.
        Diabetes Care. 1993; 16: 1231-1235
        • O'Sullivan J.B.
        Diabetes mellitus after GDM.
        Diabetes. 1991; 40: 131-135
        • Damm P.
        Predictive factors for the development of diabetes in women with previous gestational diabetes mellitus.
        Am J Obstet Gynecol. 1992; 167: 607-616
        • Santaguida P.L.
        • Balion C.
        • Hunt D.
        • et al.
        Diagnosis, prognosis, and treatment of impaired glucose tolerance and impaired fasting glucose.
        Evid Rep Technol Assess (Summ). 2005; 128: 1-11
        • American College of Obstetricians and Gynecologists
        ACOG Practice Bulletin. Clinical management guidelines for obstetrician-gynecologists. Gestational diabetes.
        Obstet Gynecol. 2001; 98: 525-538
        • American Diabetes Association
        Gestational diabetes mellitus.
        Diabetes Care. 2004; 27: S88-S90
      2. Standards of medical care in diabetes—2007.
        Diabetes Care. 2007; 30: S4-S41
        • Metzger B.E.
        • Buchanan T.A.
        • Coustan D.R.
        • et al.
        Summary and recommendations of the Fifth International Workshop-Conference on Gestational Diabetes Mellitus.
        Diabetes Care. 2007; 30: S251-S260
        • Buchanan T.A.
        (How) can we prevent type 2 diabetes?.
        Diabetes. 2007; 56: 1502-1507
        • Xiang A.H.
        • Wang C.
        • Peters R.K.
        • Trigo E.
        • Kjos S.L.
        • Buchanan T.A.
        Coordinate changes in plasma glucose and pancreatic beta-cell function in Latino women at high risk for type 2 diabetes.
        Diabetes. 2006; 55: 1074-1079
        • Festa A.
        • Williams K.
        • D'Agostino Jr, R.
        • Wagenknecht L.E.
        • Haffner S.M.
        The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study.
        Diabetes. 2006; 55: 1114-1120
        • Goldfine A.B.
        • Bouche C.
        • Parker R.A.
        • et al.
        Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease.
        PNAS. 2003; 100: 2724-2729
        • American College of Obstetricians and Gynecologists
        ACOG Committee Opinion No. 357: Primary and preventive care: periodic assessments.
        Obstet Gynecol. 2006; 108: 1615-1622
        • Gabbe S.G.
        • Gregory R.P.
        • Power M.L.
        • Williams S.B.
        • Schulkin J.
        Management of diabetes mellitus by obstetrician-gynecologists.
        Obstet Gynecol. 2004; 103: 1229-1234
        • Dinh D.T.
        • Musser J.
        • Bayliss P.M.
        Does postpartum diabetic testing occur in gestational diabetes?.
        Prim Care Update. 2003; 10: 182-185
        • Greenberg L.R.
        Gestational diabetes mellitus: antenatal variables as predictors of postpartum glucose intolerance.
        Obstet Gynecol. 1995; 86: 97-101
        • Dacus J.V.
        • Meyer N.L.
        • Muram D.
        • Stilson R.
        • Phipps P.
        • Sibai B.M.
        Gestational diabetes: postpartum glucose tolerance testing.
        Am J Obstet Gynecol. 1994; 171: 927-931
        • Kaufmann R.C.
        • Smith T.
        • Bochantin T.
        • Khardori R.
        • Evans M.S.
        • Steahly L.
        Failure to obtain follow-up testing for gestational diabetic patients in a rural population.
        Obstet Gynecol. 1999; 93: 734-737
        • Ratner R.E.
        Prevention of type 2 diabetes in women with previous gestational diabetes.
        Diabetes Care. 2007; 30: S242-S245
        • Gerstein H.C.
        • Yusuf S.
        • Bosch J.
        • et al.
        Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial.
        Lancet. 2006; 368: 1096-1105
        • Schwartz A.V.
        Thiazolidinediones: new evidence of bone loss.
        J Clin Endocrinol Metab. 2007; 92: 1232-1234
        • Schwartz A.V.
        Thiazolidinedione therapy gets complicated: is bone loss the price of improved insulin resistance?.
        Diabetes Care. 2007; 30: 1670-1671
        • Schwartz A.V.
        Thiazolidinedione use and bone loss in older diabetic adults.
        J Clin Endocrinol Metab. 2006; 91: 3349-3354
        • Solomon D.H.
        Cardiovascular risk and the thiazolidinediones: deja vu all over again?.
        JAMA. 2007; 298: 1216-1218
        • Haffner S.M.
        Incidence of type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity, and body-fat distribution.
        Diabetes. 1990; 39: 283-288
        • Polley B.A.
        • Wing R.R.
        • Sims C.J.
        Randomized controlled trial to prevent excessive weight gain in pregnant women.
        Int J Obes Relat Metab Disord. 2002; 26: 1494-1502
        • Leermakers E.A.
        • Anglin K.
        • Wing R.R.
        Reducing postpartum weight retention through a correspondence intervention.
        Int J Obes Relat Metab Disord. 1998; 22: 1103-1109
        • O'Toole M.L.
        • Sawicki M.A.
        • Artal R.
        Structured diet and physical activity prevent postpartum weight retention.
        J Womens Health. 2003; 12: 991-998
        • Gabbe S.
        • Hill L.
        • Schmidt L.
        • Schulkin J.
        Management of diabetes by obstetrician-gynecologists.
        Obstet Gynecol. 1998; 91: 643-647
        • Cheung N.W.
        • Byth K.
        Population health significance of gestational diabetes.
        Diabetes Care. 2003; 26: 2005-2009
        • Kim C.
        • Herman W.H.
        • Vijan S.
        Efficacy and cost of postpartum screening strategies for diabetes among women with histories of gestational diabetes mellitus.
        Diabetes Care. 2007; 30: 1102-1106