Objective
This study was undertaken to determine the prevalence of Y-chromosome microdeletions
in couples with recurrent pregnancy loss (RPL) as compared with fertile couples.
Study Design
Forty-three men from couples with recurrent pregnancy loss, and 43 men from couples
with a live birth and no history of miscarriages were recruited from Zekai Tahir Burak
Woman Health, Education and Research Hospital. The DNA was tested for the presence
of 4 sequence tagged sites (STSs) spanning 4 AZF regions: DYS220 (AZFb), DYS235, DYS236,
and DYS237 (AZFd).
Results
Seven (7) of the 43 men (16%) from couples with recurrent pregnancy loss had microdeletions
in 1 or more of the 4 segments studied, whereas none of the fertile men had any microdeletions
(P < .05). Their microdeletions were all found specifically at locus DYS 220 (AZFb).
Conclusion
The prevalence of the Y chromosome microdeletion in AZF region was much higher in
men from couples with recurrent pregnancy loss than men in fertile couples. This study
showed that Y chromosome microdeletion in AZF region may be a possible etiologic factor
of recurrent pregnancy loss.
Key words
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Article info
Publication history
Published online: September 26, 2008
Accepted:
June 3,
2008
Received in revised form:
April 28,
2008
Received:
January 28,
2008
Footnotes
Cite this article as: Karaer A, Karaer K, Ozaksit G, et al. Y-chromosome AZF regions microdeletions and recurrent pregnancy loss. Am J Obstet Gynecol 2008;199:662.e1-662.e5.
Reprints not available from the authors.
Identification
Copyright
© 2008 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Are Y chromosome microdeletions and recurrent pregnancy loss really associated?American Journal of Obstetrics & GynecologyVol. 201Issue 5
- PreviewWe read with great interest the article by Karaer et al,1 because Y chromosome microdeletions (YMD) and recurrent pregnancy loss (RPL) represent an interesting and poorly studied association. However, we found some weaknesses that need to be clarified: first, they used 4 sequence tagged sites (STS): 1 for the AZFb region (DYS220 [sY129]) and 3 for the AZFd region (DYS235 [sY150], DYS236 [sY152], DYS237 [sY153]). AZFd zone was proposed in 1999, but confirmed evidence shows absence of this fourth zone, and all STS referred to as AZFd used in this study correspond to AZFc zone.
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