Objective
The objective of the study was to determine whether patients undergoing chorionic
villus sampling (CVS) prior to MPR are at increased risk for adverse outcome compared
to those who did not.
Study Design
We retrospectively identified multifetal pregnancy reduction (MPR) patients from an
established database. Maternal demographic data were collected. Outcomes including
complete pregnancy loss prior to 24 weeks' gestation, gestational age at delivery,
and birthweight were analyzed.
Results
There was no significant difference in pregnancy loss between the 2 groups (CVS [4%]
vs no CVS [7%], P = .098). When stratified by finishing number, there was a significantly lower loss
rate in the singleton CVS group (2% vs 9%, P = .025) and no significant difference in reduced twins. There was no significant
difference in the average gestational age of delivery or birthweight.
Conclusion
CVS prior to MPR does not increase the risk of pregnancy loss. Our data suggest that
CVS prior to singleton reduction may decrease the risk of adverse outcome.
Key words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of Obstetrics & GynecologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Births: Final data for 2004.Natl Vital Stat Rep. 2006; 55: 1-101
- Screening for fetal chromosomal abnormalities.The College, Washington (DC)2007
- Selective reduction of multifetal pregnancies in the first trimester.N Engl J Med. 1988; 318: 1043-1047
- Genetic analysis prior to selective fetal reduction in multiple pregnancy: Technical aspects and clinical outcome.Hum Reprod. 1995; 10: 818-825
- Chorionic villus sampling before multifetal pregnancy reduction.Am J Obstet Gynecol. 2000; 183: 1078-1081
- Outcomes of first-trimester chorionic villus sampling for genetic investigation in multiple pregnancy.Ultrasound Obstet Gynecol. 2001; 17: 209-216
- First trimester transabdominal multifetal pregnancy reduction: A report of two-hundred completed cases.Am J Obstet Gynecol. 1993; 169: 17-27
- Invasive prenatal testing for aneuploidy; ACOG practice bulletin no. 88.The College, Washington (DC)2007
- First trimester fetal reduction to a singleton infant or twins: Outcome in relation to the final number and karyotyping before reduction by transabdominal chorionic villus sampling.Am J Obstet Gynecol. 2004; 191: 2035-2040
- Evolving trends in 2000 cases of multifetal pregnancy reduction: A single-center experience.Am J Obstet Gynecol. 2007; 197: 394.e1-394.e4
- Combining nuchal translucency and serum markers in prenatal screening for Down syndrome in twin pregnancies.Prenat Diagn. 2003; 23: 588-592
- Maternal serum alpha-fetoprotein and coagulation profiles multifetal pregnancy reduction.Am J Obstet Gyencol. 1993; 169: 987-990
Article Info
Publication History
Published online: July 18, 2008
Accepted:
May 27,
2008
Received in revised form:
April 25,
2008
Received:
March 1,
2008
Footnotes
Cite this article as: Ferrara L, Gandhi M, Litton C, et al. Chorionic villus sampling and the risk of adverse outcome in patients undergoing multifetal pregnancy reduction. Am J Obstet Gynecol 2008;199:408.e1-408.e4.
Identification
Copyright
© 2008 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
