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Combined adverse effect of African American race and deep stromal invasion on survival following radical hysterectomy for cervical cancer

      Objective

      The objective of the study was to explore the effect of African American race on survival following radical hysterectomy for cervical cancer.

      Study Design

      We reviewed all cases of stage IA-IIA cervical cancer treated with radical hysterectomy at our institution (1987-2001). Characteristics between races were compared using Mann Whitney U and χ2 tests. Hazard ratios (HR) of survival were calculated using Cox regression.

      Results

      We identified 134 Caucasian and 66 African American patients. There was a trend toward worse survival among African Americans (81.8% vs 88.8%, P = .165). An interaction effect between race and depth of stromal invasion was observed (P = .005), and the combination of African American race and deep stromal invasion had a powerful, independent effect on survival (HR of death 7.04 [95% confidence interval 2.48 to 19.94]).

      Conclusion

      The combination of African American race and deep stromal invasion has an adverse effect on survival following radical hysterectomy for cervical cancer and may warrant use of adjuvant therapy.

      Key words

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