Objective
The objective of the study was to review the cytologic and histopathologic features
among women 35 years of age or older with cervical dysplasia.
Study Design
Patients presenting between 2001 and 2005 were included. Patients were labeled as
pre- (PRE) or postmenopausal (POST) based on age younger than or 50 years old or older.
Statistics were performed using SAS 8.0.
Results
Three hundred fifty-nine patients were identified: 270 PRE and 89 POST. PRE and POST
patients had similar referral cytology with atypical cells of undetermined significance
(ASC)/low-grade squamous intraepithelial lesion (LSIL) in 60% and 65% and high-grade
squamous intraepithelial lesion (HSIL) in 35% and 27%, respectively. Among patients
with ASC/LSIL, POST had significantly more cervical intraepithelial neoplasia (CIN)
3 (41% vs 29%; P = .027) as well as more malignancies (17 vs 0%; P = .002). Among patients referred for loop electrical excisional procedure secondary
to HSIL cytology not explained by colposcopy, CIN 2 or greater was identified more
often in POST (71 vs 32%; P = .03).
Conclusion
Our data demonstrate a high proportion of severe cervical dysplasia in age groups
traditionally thought to have less risk than younger patients.
Key words
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Article info
Publication history
Published online: May 20, 2008
Accepted:
March 21,
2008
Received in revised form:
December 19,
2007
Received:
July 12,
2007
Footnotes
This study was supported in part by the National Center for Research Resources, National Institutes of Health, General Clinical Research Grant M01 RR-14467, and National Institutes of Health Grant N02-CP-31102 (the SUCCEED Trial).
Cite this article as: Moore KN, Bannon RJ, Lanneau GS, et al. Cervical dysplasia among women over 35 years of age. Am J Obstet Gynecol 2008;199:471.e1-471.e5.
Identification
Copyright
© 2008 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
