Objectives
The purpose of this study was to establish estimates for recurrence risk of preeclampsia
based on gestational age at delivery of the first pregnancy complicated by preeclampsia
and to determine whether interbirth interval, paternity, and body mass index (BMI)
modify that risk in women with prior preeclampsia.
Study Design
A population-based, cohort study was conducted using data from Missouri maternally
linked birth certificates. The cohort included women who had 2 singleton births between
1989 and 1997: 6157 women with preeclampsia and 97,703 women without preeclampsia
at the time of their first deliveries. Data were analyzed using the Poisson regression.
Results
At the time of their second delivery, 14.7% women with prior preeclampsia developed
recurrent preeclampsia. The risk of recurrent preeclampsia is inversely related to
gestational age at the first delivery: 38.6% for 28 weeks' gestation or earlier, 29.1%
for 29-32 weeks, 21.9% for 33-36 weeks, and 12.9% for 37 weeks or more. The recurrent
preeclampsia risk was fairly constant if both births occurred within 7 years. Obese
and overweight women had higher risks of recurrent preeclampsia (19.3% and 14.2%),
compared with women with normal BMI (11.2%). The recurrence risk did not differ according
to paternity status.
Conclusion
The risk of preeclampsia recurrence increases with earlier gestational age at the
first delivery complicated by preeclampsia and with increasing maternal BMI.
Key words
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Article Info
Publication History
Published online: February 18, 2008
Accepted:
November 27,
2007
Received in revised form:
August 31,
2007
Received:
June 4,
2007
Footnotes
Cite this article as: Mostello D, Kallogjeri D, Tungsiripat R, et al. Recurrence of preeclampsia: effects of gestational age at delivery of the first pregnancy, body mass index, paternity, and interval between births. Am J Obstet Gynecol 2008;199:55.e1-55.e7.
Reprints not available from the authors.
Identification
Copyright
© 2008 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
