Objective
The objective of the study was to assess the effectiveness of ultrasound in the antenatal
prediction of symptomatic congenital cytomegalovirus (CMV) infection.
Study Design
The sonograms of 650 fetuses from mothers with primary CMV infection were correlated
to fetal or neonatal outcome. Infection status was disclosed by viral urine isolation
at birth or CMV tissue inclusions at autopsy. Classification of symptomatic disease
was based on postnatal clinical or laboratory findings or macroscopic evidence of
tissue damage at autopsy.
Results
Ultrasound abnormalities were found in 51 of 600 mothers with primary infection (8.5%)
and 23 of 154 congenitally infected fetuses (14.9%). Symptomatic congenital infection
resulted in 1 of 23 and 68 of 131 cases with or without abnormal sonographic findings,
respectively. Positive predictive values of ultrasound vs symptomatic congenital infection
was 35.3% relating to all fetuses or infants from mothers with primary infection and
78.3% relating to fetuses or infants with congenital infection.
Conclusion
When fetal infection status is unknown, ultrasound abnormalities predict symptomatic
congenital infection in only a third of cases.
Key words
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Article Info
Publication History
Published online: January 21, 2008
Accepted:
September 27,
2007
Received in revised form:
August 1,
2007
Received:
May 6,
2007
Footnotes
Cite this article as: Guerra B, Simonazzi G, Puccetti C, et al. Ultrasound prediction of symptomatic congenital cytomegalovirus infection. Am J Obstet Gynecol 2008;198:380.e1-380.e7.
Identification
Copyright
© 2008 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Predicting congenital cytomegalovirus infection: Guerra et alAmerican Journal of Obstetrics & GynecologyVol. 198Issue 4
- PreviewThe article below summarizes a roundtable discussion of a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed: Guerra B, Simonazzi G, Puccetti C, et al. Ultrasound prediction of symptomatic congenital cytomegalovirus infection. Am J Obstet Gynecol 2008;198:380.e1-380.e7. The full discussion appears at www.AJOG.org , page e1-e3.
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