Abstract
Objective
This study was undertaken to determine effects of male aging on sperm parameters,
fertilization, pregnancy, and live birth rates among in vitro fertilization (IVF)
or gamete intrafallopian transfer (GIFT) couples. The impact of female age was also
investigated.
Study design
Prospective study was made up of 221 IVF and GIFT couples.
Results
Pregnancy rates declined as the male subjects aged. Each additional year of paternal
age was associated with 11% increased odds (P = .007) of not achieving a pregnancy, and 12% odds (P = .01) of not having a successful live birth. For first-time IVF/GIFT recipients, each
additional year of paternal age was associated with a 5% increased odds of not achieving
a pregnancy, whereas for repeaters it was 40% (P = .01). Advancing maternal age was associated with decreased numbers of oocytes retrieved
or fertilized. Women 40 years or older compared with younger than 35 years had greater
than 4-fold risk of not becoming pregnant, and greater than 20-fold risk of not achieving
a live birth.
Conclusion
Advancing paternal (and maternal) age had a deleterious effect on IVF and GIFT outcomes.
Keywords
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Article info
Publication history
Accepted:
January 21,
2004
Received in revised form:
January 12,
2004
Received:
July 24,
2003
Footnotes
☆This research was support by grant number 4RT0032 from the University of California, Office of the President, Tobacco-Related Disease Research Program, Oakland, Calif.
☆Reprints not available from the authors.
Identification
Copyright
© 2004 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
