Abstract
Objective
Menorrhagia is defined as blood loss of >80 mL, but in routine clinical practice measurement
is seldom undertaken. Our aim was to identify the features of the clinical history
that best predict menorrhagic blood loss.
Study design
A questionnaire survey of 952 menstrual complaint referrals at 3 hospital gynecology
clinics in Glasgow and Edinburgh included 226 women with putatively heavy periods
who also had consented to the measurement of their blood loss.
Results
Only 34% (95% CI, 28%-40%) of women had blood loss volume of >80 mL, but the volume
was associated with subjective heaviness of period. Logistic regression with ferritin
status, clots, and changing rate during full flow correctly predicts a loss of >80
mL for 76% of women (n = 161 patients; sensitivity, 60%; specificity, 86%). Diagnosis and treatment of patients
seem unrelated to the volume of blood loss.
Conclusion
The subjective judgment of the volume of blood loss is better than has been believed.
Clinical features can be combined to predict losses of >80 mL.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of Obstetrics & GynecologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Management of menorrhagia.University of York (Stott Brothers Ltd), Halifax, UK1995 (Effective Health Care Bulletin, vol. 1(9))
- Medical management of menorrhagia.BMJ. 1999; 319: 1343-1345
- Medical management of dysfunctional uterine bleeding.Ballieres Best Pract Res Clin Obstet Gynaecol. 2000; 13: 189-202
- Working party for guidelines for the management of heavy menstrual bleeding. An evidence based guideline for the management of heavy menstrual bleeding.N Z Med J. 1999; 112: 174-177
- Practice bulletin: management of anovulatory bleeding.Obstet Gynecol. 2000; 95: 1-8
- Treatment of menorrhagia during menstruation: randomised controlled trial of ethamsylate, mefenamic acid, and tranexamic acid.BMJ. 1996; 313: 579-582
- A comparative study of danazol, a regimen of decreasing doses of danazol and norethindrone in the treatment of objectively proven unexplained menorrhagia.Am J Obstet Gynecol. 1993; 169: 1134-1139
- A new method for measuring menstrual blood loss and its use in screening women before endometrial ablation.BJOG. 1996; 103: 1029-1033
- Randomised comparative trial of the levonorgestrel intrauterine system and norethisterone for treatment of idiopathic menorrhagia.BJOG. 1998; 105: 592-598
- A preliminary study of factors influencing perception of menstrual blood loss volume.Am J Obstet Gynecol. 1984; 149: 788-793
- Dysfunctional uterine bleeding.Ballieres Best Pract Res Clin Obstet Gynaecol. 1989; 3: 315-327
- Choice of treatment for menorrhagia.Lancet. 1999; 353: 2175-2176
- The initial management of menorrhagia. Evidence-based clinical guidelines, no. 1.Royal College of Obstetricians and Gynaecologists, London1998
- Referral for menstrual problems: cross-sectional survey of symptoms, reasons for referral, and management.BMJ. 2001; 323: 24-28
- Iron status in Danish women aged 35 to 65 years - relation to menstruation and method of contraception.Acta Obstet Gynecol Scand. 1993; 72: 610-615
- Deprivation and health in Scotland.Aberdeen University Press, Aberdeen, Scotland1991
- Determination of menstrual blood loss.Scand J Clin Lab Invest. 1964; 16: 244-248
- Sources of variation in menstrual blood loss.J Obstet Gynaecol Br Commonw. 1971; 78: 933-939
- Measurements of menstrual blood loss.Am J Obstet Gynecol. 1961; 81: 739-742
- Measurements of menstrual blood loss in patients complaining of menorrhagia.BJOG. 1977; 84: 763-768
- Estimating menstrual blood loss in women with normal and excessive menstrual fluid volume.Obstet Gynecol. 2001; 98: 806-814
- Clinical associations with objective menstrual blood volume.Eur J Obstet Gynecol Reprod Biol. 1999; 82: 73-76
- Combined laboratory and diary method for objective assessment of menstrual blood loss.Acta Obstet Gynecol Scand. 1998; 77: 201-204
- Menstrual blood loss: a population study.Acta Obstet Gynecol Scand. 1966; 45: 320-351
- Menorrhagia II: Is the 80-mL blood loss criterion useful in management of complaint of menorrhagia?.Am J Obstet Gynecol. 2004; 190: 1224-1229
Article Info
Publication History
Accepted:
November 10,
2003
Received in revised form:
June 27,
2003
Received:
March 14,
2003
Footnotes
☆Supported by the Chief Scientist's Office, Scotland (K/MRS/50/C2472).
☆Reprints not available from the authors.
Identification
Copyright
© 2004 Elsevier Inc. Published by Elsevier Inc. All rights reserved.