Does the administration of diethylstilbestrol during pregnancy have therapeutic value?

      Smith and Smith in 1949 (Am J Obstet Gynecol 1949;58:994) reported on the influence of diethylstilbestrol on the progress and outcome of pregnancy in a series of primigravidas. As controls they used a series of primigravidas who received no special treatment. They recorded the following conclusions: (1) It decreased the incidence of the late toxemias of pregnancies. (2) The premature infants born were unusually large for their gestational age. (3) The incidence of postmaturity was decreased. (4) The incidence of unexplained stillbirths was apparently decreased. (5) The neonatal death rate was decreased.
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