Objective
We sought to determine whether genetic variants associated with diabetes and obesity
predict gestational weight gain.
Study Design
A total of 960 participants in the Pregnancy, Infection, and Nutrition cohorts were
genotyped for 27 single-nucleotide polymorphisms (SNPs) associated with diabetes and
obesity.
Results
Among Caucasian and African American women (n = 960), KCNQ1 risk allele carriage was directly associated with weight gain (P < .01). In Bayesian hierarchical models among Caucasian women (n = 628), we found
posterior odds ratios >3 for inclusion of TCF2 and THADA SNPs in our models. Among African American women (n = 332), we found associations
between risk allele carriage and weight gain for the THADA and INSIG2 SNPs. In Bayesian variable selection models, we found an interaction between the
TSPAN8 risk allele and pregravid obesity, with lower weight gain among obese risk allele
carriers.
Conclusion
We found evidence that diabetes and obesity risk alleles interact with maternal pregravid
body mass index to predict gestational weight gain.
Key words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of Obstetrics & GynecologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Outcomes of maternal weight gain.Evid Rep Technol Assess. 2008; 168: 1-223
- Maternal underweight status and inadequate rate of weight gain during the third trimester of pregnancy increases the risk of preterm delivery.J Nutr. 1996; 126: 146-153
- Maternal-recalled gestational weight gain, pre-pregnancy body mass index, and obesity in the daughter.Int J Obes (Lond). 2009; 33: 743-752
- Gestational weight gain, macrosomia, and risk of cesarean birth in nondiabetic nulliparas.Obstet Gynecol. 2004; 104: 671-677
- Pregnancy outcome and weight gain recommendations for the morbidly obese woman.Obstet Gynecol. 1998; 91: 97-102
- Maternal obesity and diabetes as risk factors for adverse pregnancy outcomes: differences among 4 racial/ethnic groups.Am J Public Health. 2005; 95: 1544-1661
- A prospective assessment of metabolic function, compliance with gestational weight gain guidelines, and associated pregnancy outcomes.Am J Obstet Gynecol. 2006; 195: S82
- Effect of body mass index and excessive weight gain on success of vaginal birth after cesarean delivery.Obstet Gynecol. 2005; 106: 741-746
- The relative importance of gestational gain and maternal characteristics associated with the risk of becoming overweight after pregnancy.Int J Obes Relat Metab Disord. 2000; 24: 1660-1668
- Sociodemographic, perinatal, behavioral, and psychosocial predictors of weight retention at 3 and 12 months postpartum.Obesity (Silver Spring). 2009 Dec 24; ([Epub ahead of print])
- Excess pregnancy weight gain and long-term obesity: one decade later.Obstet Gynecol. 2002; 100: 245-252
- Impact of perinatal weight change on long-term obesity and obesity-related illnesses.Obstet Gynecol. 2005; 106: 1349-1356
- Maternal weight gain and preterm delivery: differential effects by body mass index.Epidemiology. 1999; 10: 141-147
- Pregnancy complications and birth outcomes in obese and normal-weight women: effects of gestational weight change.Obstet Gynecol. 1996; 87: 389-394
- Increased neonatal fat mass, not lean body mass, is associated with maternal obesity.Am J Obstet Gynecol. 2006; 195: 1100-1103
- Gestational weight gain and child adiposity at age 3 years.Am J Obstet Gynecol. 2007; 196: 322.e1-322.e8
- Genetics of common forms of obesity: a brief overview.Am J Clin Nutr. 2005; 82: 215S-217S
- A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.Science. 2007; 316: 889-894
- Common variants near MC4R are associated with fat mass, weight and risk of obesity.Nat Genet. 2008; 40: 768-775
- A common genetic variant is associated with adult and childhood obesity.Science. 2006; 312: 279-283
- Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.Nat Genet. 2009; 41: 25-34
- Genome-wide association studies provide new insights into type 2 diabetes etiology.Nat Rev. 2007; 8: 657-662
- Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.Nat Genet. 2008; 40: 638-645
- SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.Nat Genet. 2008; 40: 1098-1102
- Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.Nat Genet. 2008; 40: 1092-1097
- A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels.Science. 2008; 320: 1085-1088
- Effect of macronutrient intake on the development of glucose intolerance during pregnancy.Am J Clin Nutr. 2004; 79: 479-486
- Nutrition during pregnancy.National Academies Press, Washington, DC1990
- Institute of Medicine maternal weight gain recommendations and pregnancy outcome in a predominantly Hispanic population.Obstet Gynecol. 1994; 84: 565-573
- The relationship between pregnancy weight gain and glucose tolerance status among black and white women in central North Carolina.Am J Obstet Gynecol. 2006; 195: 1629-1635
- Dietary energy density but not glycemic load is associated with gestational weight gain.Am J Clin Nutr. 2008; 88: 693-699
- Psychosocial determinants of adequacy of gestational weight gain.Obesity (Silver Spring). 2009; 17: 300-309
- Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men.Diabetes. 2007; 56: 1460-1467
- The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.PLoS Genet. 2007; 3: e61
- Association studies of common variants in 10 hypogonadotropic hypogonadism genes with age at menarche.J Clin Endocrinol Metab. 2008; 93: 4290-4298
- Inference of population structure using multilocus genotype data.Genetics. 2000; 155: 945-959
- PPAR-gamma2 Pro12Ala polymorphism is associated with weight gain in women with gestational diabetes mellitus.Eur J Obstet Gynecol Reprod Biol. 2006; 129: 25-30
- Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.Nat Rev Mol Cell Biol. 2008; 9: 367-377
- Review: peroxisome proliferator-activated receptor gamma and adipose tissue—understanding obesity-related changes in regulation of lipid and glucose metabolism.J Clin Endocrinol Metab. 2007; 92: 386-395
- Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy.Am J Physiol. 2002; 282: E522-E533
- Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion.Diabetes. 2009; 58: 1715-1720
- The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women.Hum Mol Genet. 2008; 17: 3502-3508
- Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry.Obesity (Silver Spring). 2009; 17: 1461-1465
Article Info
Publication History
Accepted:
June 29,
2010
Received in revised form:
May 14,
2010
Received:
March 2,
2010
Footnotes
This study received support from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (Grant nos. HD28684 , HD28684A , HD37584 , and HD39373 ); the National Institute of Diabetes and Digestive and Kidney Diseases (Grant nos. DK61981 and DK56350 ); the National Cancer Institute (Grant no. CA109804-01 ); the General Clinical Research Center, National Institute of Health (Grant no. RR00046 ); the Carolina Population Center ; the University of North Carolina University Research Council ; and the Nutrition and Obesity Research Council (Grant no. DK056350 ). Dr Stuebe receives support from the Women's Reproductive Health Research Career Development Center at University of North Carolina ( 5K12HD050113-04 ). Dr Ghosh receives support from National Institute of Environmental Health Sciences 5T32ES007018 and National Institute of Environmental Health Sciences P30 ES10126 .
Cite this article as: Stuebe AM, Lyon H, Herring AH, et al. Obesity and diabetes genetic variants associated with gestational weight gain. Am J Obstet Gynecol 2010;203:283.e1-17.
Identification
Copyright
© 2010 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
