We conducted a metaanalysis of published studies on the relation between coffee drinking
and endometrial cancer risk, which included 2 cohort (201 cases) and 7 case-control
studies (2409 cases). The summary relative risk (RR) for coffee drinkers vs nondrinkers
was 0.80 (95% confidence interval [CI], 0.68-0.94), with significant heterogeneity
between studies. Compared with nondrinkers, the summary RR was 0.87 (95% CI, 0.78-0.97)
for low-to-moderate coffee drinkers and 0.64 (95% CI, 0.48-0.86) for heavy coffee
drinkers. The summary RR for an increase of 1 cup/d was 0.93 (95% CI, 0.89-0.97),
which suggests an inverse relation between coffee and endometrial cancer. However,
the causality must be confirmed.
Key words
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References
- Coffee and cancer risk: an update.Eur J Cancer Prev. 2007; 16: 385-389
- Coffee and cancer: a prospective study of 43,000 Norwegian men and women.Cancer Causes Control. 1994; 5: 401-408
- Coffee consumption and risk of endometrial cancer: a prospective study in Japan.Int J Cancer. 2008; 123: 2406-2410
- Coffee consumption and the risk of endometrial cancer: evidence from a case-control study of female hormone-related cancers in Japan.Cancer Sci. 2007; 98: 411-415
- Case-control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma.Eur J Cancer Prev. 2008; 17: 358-363
- Dietary factors and the risk of endometrial cancer.Cancer. 1993; 71: 3575-3581
- Diet in relation to endometrial cancer risk: a case-control study in Greece.Nutr Cancer. 2002; 44: 16-22
- Why is endometrial cancer less common in Greece than in other European Union countries?.Eur J Cancer Prev. 2002; 11: 427-432
- Food groups and endometrial cancer risk: a case-control study from Italy.Am J Obstet Gynecol. 2008; ([In press])
- Nutritional factors and endometrial cancer in Ontario, Canada.Cancer Control. 2000; 7: 288-296
- Dietary factors in relation to endometrial cancer: a nationwide case-control study in Sweden.Nutr Cancer. 2002; 42: 25-32
- Diet, body size, physical activity, and the risk of endometrial cancer.Cancer Res. 1997; 57: 5077-5085
- Dietary factors and endometrial cancer risk.Int J Gynecol Cancer. 2005; 15: 938-945
- Publication bias in meta-analysis: its causes and consequences.J Clin Epidemiol. 2000; 53: 207-216
- Bias in meta-analysis detected by a simple, graphical test.BMJ. 1997; 315: 629-634
- Quantitative methods in the review of epidemiologic literature.Epidemiol Rev. 1987; 9: 1-30
- Meta-analysis in clinical trials.Control Clin Trials. 1986; 7: 177-188
- Methods for trend estimation from summarized dose-response data, with applications to meta-analysis.Am J Epidemiol. 1992; 135: 1301-1309
- Endometrial cancer.in: Schottenfeld D. Fraumeni Jr, J.F. Cancer epidemiology and prevention. 3rd ed. Oxford University Press, New York2006: 1027-1043
- Global cancer statistics, 2002.CA Cancer J Clin. 2005; 55: 74-108
- Coffee drinking and hepatocellular carcinoma risk: a meta-analysis.Hepatology. 2007; 46: 430-435
- Coffee consumption and risk of liver cancer: a meta-analysis.Gastroenterology. 2007; 132: 1740-1745
- Meta-analysis of coffee consumption and risk of colorectal cancer.Am J Epidemiol. 1998; 147: 1043-1052
- Coffee and tea intake and risk of cancers of the colon and rectum: a study of 3,530 cases and 7,057 controls.Int J Cancer. 1997; 73: 193-197
- Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity.Food Chem Toxicol. 2002; 40: 1155-1163
- Caffeine intake and endogenous sex steroid levels in postmenopausal women: the Rancho Bernardo study.Am J Epidemiol. 1996; 144: 642-644
- Association of coffee, green tea, and caffeine intakes with serum concentrations of estradiol and sex hormone-binding globulin in premenopausal Japanese women.Nutr Cancer. 1998; 30: 21-24
- The antiestrogenic effect of cigarette smoking in women.Am J Obstet Gynecol. 1990; 162: 502-514
- The composition of coffee.in: Garattini S. Caffeine, coffee and health. Raven Press, Ltd, New York1993: 17-41
- Chlorogenic acid modifies plasma and liver concentrations of: cholesterol, triacylglycerol, and minerals in (fa/fa) Zucker rats.J Nutr Biochem. 2002; 13: 717-726
- A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk.Med Hypotheses. 2005; 64: 848-853
- Caffeinated coffee, decaffeinated coffee, and caffeine in relation to plasma C-peptide levels, a marker of insulin secretion, in U.S. women.Diabetes Care. 2005; 28: 1390-1396
- Coffee consumption and risk of type 2 diabetes: a systematic review.JAMA. 2005; 294: 97-104
- Reproductive, menstrual, and medical risk factors for endometrial cancer: results from a case-control study.Am J Obstet Gynecol. 1992; 167: 1317-1325
- Diabetes and risk of endometrial cancer: a population-based prospective cohort study.Cancer Epidemiol Biomarkers Prev. 2007; 16: 276-280
- A case-control study of diabetes mellitus and cancer risk.Br J Cancer. 1994; 70: 950-953
- Diabetes and endometrial cancer: effect modification by body weight, physical activity and hypertension.Br J Cancer. 2007; 97: 995-998
- Diabetes and endometrial cancer: an Italian case-control study.Int J Cancer. 1999; 81: 539-542
- Case-control study of diabetes, obesity, physical activity and risk of endometrial cancer among Mexican women.Cancer Causes Control. 2000; 11: 707-711
- Reliability of information on cigarette smoking and beverage consumption provided by hospital controls.Epidemiology. 1996; 7: 312-315
- Reproducibility and validity of coffee and tea consumption in Italy.Eur J Clin Nutr. 2004; 58: 674-680
Article Info
Publication History
Published online: December 29, 2008
Accepted:
October 7,
2008
Received in revised form:
September 23,
2008
Received:
June 20,
2008
Footnotes
This work was conducted with the contribution of the Italian Association for Cancer Research, and the Italian League Against Cancer. The work of this paper was undertaken while CLV was a Senior Fellow at the International Agency for Research on Cancer (IARC).
Authorship and contribution to the manuscript is limited to the 7 authors indicated. There was no outside funding or technical assistance with the production of this article.
Identification
Copyright
© 2009 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
