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Occupational factors and risk of preterm birth in nurses

Published:November 03, 2008DOI:https://doi.org/10.1016/j.ajog.2008.08.006

      Objective

      We evaluated first-trimester exposures and the risk of preterm birth in the most recent pregnancy of participants of the Nurses' Health Study II.

      Study Design

      Log binomial regression was used to estimate the relative risk (RR) for preterm birth in relation to occupational risk factors, such as work schedule, physical factors, and exposures to chemicals and x-rays, adjusted for age and parity.

      Results

      Part-time work (≤ 20 hours a week) was associated with a lower risk of preterm birth [RR, 0.7; 95% confidence interval [CI], 0.6-0.9]. Working nights was associated only with early preterm birth (< 32 weeks of gestation) (RR, 3.0; 95% CI, 1.4-6.2). Although based on only 11 exposed preterm cases, self-reported exposure to sterilizing agents was associated with an increased risk (RR, 1.9; 95% CI, 1.1-3.4).

      Conclusion

      These data suggest that night work may be related to early but not late preterm birth, whereas physically demanding work did not strongly predict risk.

      Key words

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