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Abstract
OBJECTIVE: Our purpose was to determine whether patients with severe early-onset preeclampsia
have hemostatic or metabolic abnormalities that are associated with a tendency to
vascular thrombosis.
STUDY DESIGN: A total of 101 patients with a history of severe early-onset preeclampsia were tested
at least 10 weeks post partum for the presence of hyperhomocysteinemia (methionine
loading test), protein C, protein S, and antithrombin III deficiency, activated protein
C resistance, lupus anticoagulant, and immunoglobulin G and/or M anticardiolipin antibodies.
RESULTS: Of the 101 patients, 39 (38.6%) had chronic hypertension. Of the 85 patients tested
for coagulation disturbances, 21 (24.7%) had protein S deficiency. Of the 50 patients
tested for activated protein C resistance, 8 (16.0%) were positive. Of the 79 patients
tested for hyperhomocysteinemia, 14 (17.7%) had a positive methionine loading test.
Finally, 95 patients were tested for anticardiolipin antibodies; 27 (29.4%) had detectable
immunoglobulin G and/or M anticardiolipin antibodies.
CONCLUSION: Patients with a history of severe early-onset preeclampsia should be screened for
protein S deficiency, activated protein C resistance, hyperhomocysteinemia, and anticardiolipin
antibodies, since these results may have an impact on counseling for and pharmacologic
management in future pregnancies.
Keywords
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Article Info
Footnotes
☆Presented at the Fifteenth Annual Meeting of the Society of Perinatal Obstetricians, Atlanta, Georgia, January 23–28, 1995.
Identification
Copyright
© 1995 Published by Elsevier Inc.
