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Factors associated with preterm birth in Cardiff, Wales

I. Univariable and multivariable analysis
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      Abstract

      OBJECTIVE: Our purpose was to examine the associations of demographic, social, and medical factors with risk of preterm birth.
      STUDY DESIGN: By use of the Cardiff Births Survey, a large database of largely homogeneous (white) births in Wales, multivariable analysis by logistic regression examined the relative importance of risk variables associated with preterm birth.
      RESULTS: Significant independent associations with preterm birth were found (in decreasing order of magnitude) for late pregnancy bleeding, preeclampsia-proteinuria, low maternal weight, low maternal age, early pregnancy bleeding, history of previouss stillbirth, smoking, high parity, low or high hemoglobin concentration, history of previous abortion, low social class, bacteriuria, and nulliparity.
      CONCLUSION: In this population demographic, social, and medical characteristics of the pregnancies showed significant associations with preterm birth.

      Keywords

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      References

        • Rush RW
        • Davey DA
        • Segall ML
        The effect of preterm delivery on perinatal mortality.
        Br J Obstet Gynaecol. 1978; 85: 806-811
        • McCormick MC
        The contribution of low birth weight to infant mortality and childhood morbidity.
        N Engl J Med. 1985; 312: 82-89
        • Kaminski M
        • Goujard J
        • Rumeau-Rouquette C
        Prediction of low birthweight and prematurity by a multiple regression analysis with maternal characteristics known since the beginning of the pregnancy.
        Int J Epidemiol. 1973; 2: 195-204
        • Berkowitz GS
        Clinical and obstetric risk factors for preterm delivery.
        Mt Sinai J Med. 1985; 52: 239-247
        • Ross MG
        • Hobel CJ
        • Bragonier JR
        • Bear MB
        • Bemis RL
        A simplified risk-scoring system for prematurity.
        Am J Perinatol. 1986; 3: 339-344
        • Cnattingius S
        • Forman MR
        • Berendes HW
        • Graubard BI
        • Isotalo L
        Effect of age, parity, and smoking on pregnancy outcome: a population-based study.
        Am J Obstet Gynecol. 1993; 168: 16-21
        • Andrews J
        • Davies K
        • Chalmers I
        • Campbell H
        The Cardiff Birth Survey.
        in: Harper PS Sunderland E Genetic and population studies in Wales. University of Wales Press, Cardiff1985: 317-341
        • Butler NR
        • Bonham DG
        Perinatal problems: the first report of the 1958 British perinatal mortality survey.
        in: E&S Livingstone, Edinburgh1963: 116
        • Chamberlain G
        • Philipp E
        • Howlett B
        • Masters K
        British birth 1970: obstetric care.
        William Heinemann, London1970
        • Bréart G
        Evaluation of the preterm birth rate in France.
        in: Berendes HW Kessel MHS Yaffe S Advances in the prevention of low birthweight: an international symposium. National Center for Education in Maternal and Child Health, Washington1991: 13-25
        • Hoffman HJ
        • Bakketeig LS
        Risk factors associated with the occurrence of preterm birth.
        Clin Obstet Gynecol. 1984; 27: 539-552
        • Berkowitz GS
        • Harlpa S
        • Beck GL
        • Freeman DH
        • Baras M
        Early gestational bleeding and pregnancy outcome: a multivariable analysis.
        Int J Epidemiol. 1983; 12: 165-173
        • Niswander KR
        • Gordon M
        The women and their pregnancies: the collaborative perinatal study of the National Institute of Neurological Diseases and Stroke.
        National Institute of Health, Besthesda, Maryland1972 (DHEW publication no 73-379)
        • Teitelman AM
        • Welch LS
        • Hellenbrand KG
        • Bracken MB
        Effect of maternal work activity on preterm birth and low birth weight.
        Am J Epidemiol. 1990; 131: 104-113
        • Goldenberg RL
        • Davis RO
        • Copper RL
        • Corliss DK
        • Andrews JB
        • Carpenter AH
        The Alabama preterm birth prevention project.
        Obstet Gynecol. 1990; 75: 933-939
        • Klebanoff MA
        • Shiono PH
        • Carey JC
        The effect of physical activity during pregnancy on preterm delivery and birth weight.
        Am J Obstet Gynecol. 1990; 163: 1450-1456
        • Moore ML
        • Michielutte R
        • Meis PJ
        • Ernest JM
        • Wells HB
        • Buescher PA
        Etiology of low birthweight birth: a population based study.
        Prev Med. 1994; 23: 793-799
        • Papiernik E
        • Kaminski M
        Multifactorial study of the risk of prematurity at 32 weeks of gestation, I: a study of the frequency of 30 predictive characteristics.
        J Perinat Med. 1974; 2: 30-36
        • Peters TJ
        • Golding J
        • Butler NR
        • Fryer JG
        • Lawrence CJ
        • Chamberlain GVP
        Plus ca change: predictors of birthweight in two national studies.
        Br J Obstet Gynaecol. 1983; 90: 1040-1045
        • Fedrick J
        • Anderson ABM
        Factors associated with spontaneous pre-term birth.
        Br J Obstet Gynaecol. 1976; 83: 342-350
        • Paz JE
        • Otano L
        • Gadow EC
        • Castilla EE
        Previous miscarriage and stillbirth as risk factors for other unfavourable outcomes in the next pregnancy.
        Br J Obstet Gynaecol. 1992; 99: 808-812
        • Stettler RW
        • Cunningham FG
        Natural history of chronic proteinuria complicating pregnancy.
        Am J Obstet Gynecol. 1992; 167: 1219-1224
        • Page EW
        • Christianson R
        Influence of blood pressure changes with and without proteinuria upon outcome of pregnancy.
        Am J Obstet Gynecol. 1976; 126: 821-833
        • Hertz JB
        • Leisterberg L
        The outcome of pregnancy after threatened abortion.
        Acta Obstet Gynecol Scand. 1985; 64: 151-156
        • Williams MA
        • Mittendorf R
        • Lieberman E
        • Monson RR
        Adverse infant outcomes associated with first-trimester vaginal bleeding.
        Obstet Gynecol. 1991; 78: 14-18
        • Hauth JC
        • Goldenberg RL
        • Parker Jr, R
        • et al.
        Low-dose aspirin therapy to prevent preeclampsia.
        Am J Obstet Gynecol. 1993; 168: 1083-1093
        • Sibai BM
        • Caritis SN
        • Thom E
        • et al.
        Prevention of preeclampsia with low-dose aspirin in healthy, nulliparous pregnant women.
        N Engl J Med. 1993; 329: 1213-1218
        • CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group
        CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women.
        Lancet. 1994; 343: 619-629